{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:55:17Z","timestamp":1777924517021,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      \n                      \n                      COVID-19, caused by the SARS-CoV-2 virus, has resulted in a global public health crisis with a wide spectrum of clinical manifestations, ranging from asymptomatic infections to severe pneumonia. This study explores the association between various biomarkers and COVID-19 progression, aiming to identify early indicators of disease severity and enhance patient management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The study included 750 confirmed COVID-19 patients categorized into four groups based on disease severity. Patients were recruited at the General Hospital in Te\u0161anj, Bosnia and Herzegovina. All biochemical, hematological and coagulation parameters were analyzed using standard IFCC protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study identified significant differences in biochemical, hematological, and coagulation biomarkers across varying COVID-19 severities. Key markers such as C-reactive protein (CRP), D-dimer, lymphocyte count, erythrocyte sedimentation rate (ESR), and platelet count were analyzed. Elevated CRP and D-dimer were strongly linked to severe cases, while decreased lymphocyte count, elevated ESR, and platelet abnormalities were also associated with increased disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study highlights the vital role of specific biochemical, hematological and coagulation parameters in predicting COVID-19 severity. Integrating these findings into clinical practice could enhance timely risk stratification, early intervention, and improved outcomes for affected individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251327481","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T03:32:14Z","timestamp":1745983934000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Insights into biochemical, hematological, and coagulation parameters and their association with COVID-19 severity within four patients cohort from Bosnia and Herzegovina"],"prefix":"10.1177","author":[{"given":"Neven","family":"Meseld\u017ei\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical biochemistry and laboratory diagnostics, University of Sarajevo, Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Besim","family":"Prnjavorac","sequence":"additional","affiliation":[{"name":"General Hospital Te\u0161anj, Te\u0161anj, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Duji\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical biochemistry and laboratory diagnostics, University of Sarajevo, Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Malenica","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical biochemistry and laboratory diagnostics, University of Sarajevo, Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lejla","family":"Prnjavorac","sequence":"additional","affiliation":[{"name":"General Hospital Te\u0161anj, Te\u0161anj, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Bedak","sequence":"additional","affiliation":[{"name":"General Hospital Te\u0161anj, Te\u0161anj, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Imamovi\u0107-Kadri\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical biochemistry and laboratory diagnostics, University of Sarajevo, Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damir","family":"Marjanovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Anthropological Research, Zagreb, Croatia"},{"name":"Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina"},{"name":"Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1350-7084","authenticated-orcid":false,"given":"Tamer","family":"Bego","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical biochemistry and laboratory diagnostics, University of Sarajevo, Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30260-9"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2003.03011"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12758"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.5937\/jomb0-29341"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/20503121221108613"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087099"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.607647"},{"key":"e_1_3_4_10_2","first-page":"580","article-title":"An analysis of hematological, coagulation and biochemical markers in COVID-19 disease and their association with clinical severity and mortality: an Indian outlook","volume":"11","author":"Pujani M","year":"2021","unstructured":"Pujani M, Raychaudhuri S, Singh M, et\u00a0al. 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