{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:46:10Z","timestamp":1792028770258,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) in the elderly necessitates innovative therapeutic technologies to address systemic complications. Advanced hemodialysis systems, integrating real-time biochemical monitoring and optimized filtration, offer potential enhancements in clinical outcomes, yet their impact on inflammatory pathways and metabolic equilibrium remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study evaluated the efficacy of a next-generation hemodialysis system in modulating inflammatory biomarkers, renal function parameters, and calcium-phosphorus homeostasis among elderly CKD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eighty-four elderly CKD patients were randomized into a control group (standard therapy) and an intervention group (standard therapy\u2009+\u2009advanced hemodialysis). The intervention utilized a fully automated dialysis machine with bicarbonate dialysate, precision-calibrated blood flow (180\u2013200 mL\/min), and real-time metabolic tracking. Serum levels of TNF-\u03b1, IL-6, IL-1, hs-CRP, BUN, Scr, \u03b22-MG, calcium, phosphorus, and Ca\u2009\u00d7\u2009P were analyzed pre- and post-intervention using ELISA and biochemical assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The intervention group demonstrated a higher total efficacy rate (85.71% vs. 64.29%, P\u2009&lt;\u20090.05). Post-treatment, significant reductions in inflammatory markers (TNF-\u03b1: 1.35\u2009\u00b1\u20090.24 vs. 4.06\u2009\u00b1\u20090.42 ng\/mL; IL-6: 13.05\u2009\u00b1\u20091.52 vs. 17.62\u2009\u00b1\u20092.24 ng\/L), renal toxins (BUN: 7.82\u2009\u00b1\u20091.75 vs. 10.12\u2009\u00b1\u20092.02 mmol\/L; Scr: 401.32\u2009\u00b1\u200915.76 vs. 489.95\u2009\u00b1\u200916.14 \u03bcmol\/L), and phosphorus (1.62\u2009\u00b1\u20090.34 vs. 2.16\u2009\u00b1\u20090.46 mmol\/L) were observed (P\u2009&lt;\u20090.05). Calcium levels improved (3.19\u2009\u00b1\u20090.56 vs. 2.26\u2009\u00b1\u20090.53 mmol\/L), alongside stabilized Ca\u2009\u00d7\u2009P products (52.92\u2009\u00b1\u20095.05 vs. 60.34\u2009\u00b1\u20097.06 mg\n                      <jats:sup>2<\/jats:sup>\n                      \/dL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Advanced hemodialysis systems significantly enhance therapeutic outcomes in elderly CKD patients by attenuating inflammation, restoring renal function, and optimizing calcium-phosphorus metabolism. These findings underscore the clinical value of integrating technology-driven dialysis protocols for precision care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251332413","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:06:21Z","timestamp":1745899581000},"page":"2177-2183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced hemodialysis systems: Assessing inflammatory biomarkers, renal analytics, and metabolic stability in elderly patients with chronic kidney disease"],"prefix":"10.1177","volume":"33","author":[{"given":"Hong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Anhui Medical University Affiliated Anqing First People's Hospital, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Anhui Medical University Affiliated Anqing First People's Hospital, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Anhui Medical University Affiliated Anqing First People's Hospital, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13783"},{"key":"e_1_3_2_3_2","first-page":"226","article-title":"Efficacy and safety analysis of alfacalcidol combined with cinacalcet in the treatment of secondary hyperparathyroidism in patients with chronic renal failure in maintenance hemodialysis","volume":"84","author":"Tong J","year":"2022","unstructured":"Tong J, Zheng X. Efficacy and safety analysis of alfacalcidol combined with cinacalcet in the treatment of secondary hyperparathyroidism in patients with chronic renal failure in maintenance hemodialysis. Indian J Pharm Sci. 2022; 84: 226\u2013231.","journal-title":"Indian J Pharm Sci."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-021-01735-y"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077409"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/THC-229011"},{"key":"e_1_3_2_7_2","unstructured":"Lejla G Vukovic D Dzemic Z et al. 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A case of insidious onset of Kimura disease-associated immunoglobulin A nephropathy without eosinophil infiltration in the renal tissue. Iran J Allergy Asthm 2023; 22: 604\u2013608.","journal-title":"Iran J Allergy Asthm"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.19.03690-5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15352"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15015"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13727"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30559"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000528763"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.07.024"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000528983"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2022.0024"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.07.010"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2021.1975741"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15110"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13493"}],"container-title":["Technology and Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09287329251332413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09287329251332413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09287329251332413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:28:40Z","timestamp":1792027720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09287329251332413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/09287329251332413"],"URL":"https:\/\/doi.org\/10.1177\/09287329251332413","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]}}}