{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:55:25Z","timestamp":1777924525743,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chemotherapy-induced nausea and vomiting (CINV) remains a prevalent and debilitating side effect of cancer treatment with limited therapeutic options. Dingxiang Shidi Decoction (DXSD), a classical Chinese herbal formula, has demonstrated clinical efficacy in CINV management. However, its active components and mechanism of action require systematic investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to elucidate the pharmacologically active constituents of DXSD and their anti-CINV mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We employed advanced analytical techniques including UPLC-MS\/MS and GC-MS to analyze the chemical components of DXSD. Network pharmacology techniques were applied to explore its pharmacological mechanisms. And molecular docking simulation was conducted to further refine the drug-target interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 292 chemical compounds were identified in DXSD, comprising 165 water-soluble components, 56 volatile components, and 84 network database entries. By integrating 564 drug targets with 888 CINV disease targets, we identified 143 potential therapeutic targets. Further protein-protein interaction (PPI) network analysis revealed 12 key active ingredients and 13 key therapeutic targets. Enrichment analysis suggested that DXSD may reduce inflammation, modulate neurotransmitter stimulation in the gastrointestinal tract, and regulate cellular proliferation and differentiation. Notably, key active ingredients, predominantly aromatic compounds such as sabinene, (-)-\u03b1-cubebene, \u03b1-copaene, \u03b2-caryophyllene, aromandendrene, \u03b3-muurolene, (-)-\u03b1-muurolene, \u03b1-phellandrene, \u03b1-terpinene, \u03b3-terpinene, (+)-\u03b4-cadinene, and Gomisin B, demonstrated significant binding affinity with multiple targets, particularly AKT1, BCL2, EGFR, MTOR, and STAT3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reveals the active components and therapeutic mechanisms of DXSD against CINV, supporting its clinical application and demonstrating the potential of aromatherapy as an effective treatment strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251358624","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T08:31:01Z","timestamp":1752654661000},"page":"51-62","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering the mechanism and substance basis of Dingxiang Shidi Decoction for the treatment of chemotherapy-induced nausea and vomiting by integrating mass spectrometry, network pharmacology and molecular docking"],"prefix":"10.1177","volume":"34","author":[{"given":"Min","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Province Military Region Jinan Eighth Retired Cadres Rest, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zemin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.2592"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-020-00202-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.12.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2020.100278"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03543-y"},{"key":"e_1_3_3_7_2","first-page":"232","article-title":"Chemotherapy-induced nausea and vomiting: optimizing prevention and management","volume":"5","author":"Rao KV","year":"2012","unstructured":"Rao KV, Faso A. 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