{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:55:27Z","timestamp":1777924527418,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fundamental Research Funds for Science and Technology in Xuzhou","award":["No. KC20191"],"award-info":[{"award-number":["No. KC20191"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"abstract":"<jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Budd-Chiari syndrome (BCS) presents challenges in postoperative restenosis risk prediction due to unclear hemodynamic pathophysiology. Despite advances in interventional therapies, tools linking hemodynamic abnormalities to vascular remodeling are lacking. This study aimed to evaluate hemodynamic changes in BCS patients with inferior vena cava (IVC) stenosis using patient-specific MRI and computational fluid dynamics (CFD) to establish predictive biomarkers and optimize management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>3D IVC models were reconstructed from preoperative, postoperative, and healthy control MRI data. Dynamic hemodynamic parameters, including flow velocity, pressure gradients, wall shear stress (WSS), and vortex patterns, were analyzed via CFD simulations under physiologically accurate boundary conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preoperative IVC stenosis caused severe disturbances. Post-intervention, parameters decreased (e.g., peak stenotic velocity from 1.91 m\/s to 0.97 m\/s; trans-stenotic pressure gradient from 3562 Pa to 1404 Pa) but remained higher than normal (peak velocity: 0.27 m\/s; pressure fluctuation: \u03941225 Pa). Persistent vortices near stent edges and incomplete pressure normalization were observed, correlating with restenosis incidence. These findings highlight unresolved WSS (post-op peak WSS: 18.2 Pa vs normal: 6.18 Pa) and abnormal flow dynamics (e.g., prolonged vortex duration) as key recurrence risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides a hemodynamic framework for BCS, showing that intervention alleviates stenosis but doesn't restore normal flow. Residual stress emphasizes the need for adjunct therapies. The CFD approach offers predictive insights, advocating personalized monitoring for improved BCS outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251360084","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T06:48:38Z","timestamp":1752821318000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamics and restenosis risk assessment in Budd-Chiari syndrome: A CFD study"],"prefix":"10.1177","author":[{"given":"Shikun","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"},{"name":"Department of Ultrasound, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"},{"name":"Department of Ultrasound, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyue","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingrong","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbin","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijun","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghong","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.040"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020282"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2018.08.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.12.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.051"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-019-0791-x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13132256"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7599.2007.00250.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.24926\/iip.v12i2.3906"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-021-02932-z"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9609"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i30.10628"},{"key":"e_1_3_3_14_2","first-page":"299","article-title":"Budd-Chiari syndrome: reassessment of a step-wise treatment strategy","volume":"78","author":"Martens P","year":"2015","unstructured":"Martens P, Maleux GA, Devos T, et\u00a0al. 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