{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:05:33Z","timestamp":1788264333924,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional dyspepsia (FD) is a prevalent gastrointestinal disorder associated with impaired motility, mucosal barrier disruption, and dysbiosis of intestinal microbiota. While pharmacological treatments exist, non-invasive therapeutic approaches leveraging traditional medicine are gaining attention for their holistic benefits and minimal side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the therapeutic impact of abdominal massage, a non-pharmacological intervention rooted in Traditional Chinese Medicine (TCM), on gastrointestinal motility, duodenal barrier integrity, and gut microbiota in a rat model of FD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen male rats were assigned to control, model, and massage groups. The FD model was established via multifactorial stress. The massage group underwent daily abdominal massage for 7 days. Food intake, body weight, gastric emptying, and intestinal propulsion were assessed. Duodenal tissue morphology, expression of tight junction proteins (occludin and claudin-1), and intestinal microbiota profiles (via 16S rRNA sequencing) were analyzed using histological, immunofluorescence, and high-throughput sequencing technologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Abdominal massage significantly improved gastric emptying and intestinal propulsion in FD rats. Histological examination revealed restoration of duodenal villi architecture, and immunofluorescence showed increased expression of occludin and claudin-1. Microbiota analysis suggested a shift toward a more balanced community, with trends indicating increased abundance of beneficial taxa such as Enterococcaceae and Lachnospiraceae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abdominal massage effectively enhances gastrointestinal motility, suggests potential to promote intestinal microbiota homeostasis, and repairs mucosal barrier dysfunction in FD rats. These findings suggest the potential of massage therapy as a safe, non-invasive, and technologically integrable modality in the management of gastrointestinal disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251363139","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T07:05:13Z","timestamp":1754636713000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of abdominal massage as a non-pharmacological modality to restore gut microbiota and duodenal barrier function in a rat model of functional dyspepsia"],"prefix":"10.1177","author":[{"given":"Xurong","family":"Liang","sequence":"first","affiliation":[{"name":"Acupuncture and Moxibustion Massage College of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu-A","family":"Yang","sequence":"additional","affiliation":[{"name":"Changchun Humanities and Sciences College, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu-B","family":"Yang","sequence":"additional","affiliation":[{"name":"Changchun Humanities and Sciences College, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Acupuncture and Moxibustion Massage College of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Yang","sequence":"additional","affiliation":[{"name":"Acupuncture and Moxibustion Massage College of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_3_2_3_2","first-page":"1147","article-title":"Effects of sumac aqueous extract along with eating and drinking modification on functional dyspepsia symptoms in comparison with omeprazole: an open-label, randomized, controlled clinical trial","volume":"15","author":"Saravani M","year":"2025","unstructured":"Saravani M, Memariani Z, Behnampour N, et al. Effects of sumac aqueous extract along with eating and drinking modification on functional dyspepsia symptoms in comparison with omeprazole: an open-label, randomized, controlled clinical trial. Avicenna J Phytomedi 2025; 15: 1147\u20131166.","journal-title":"Avicenna J Phytomedi"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i13.1517"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327737"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000269822"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1752181"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.02.004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.944591"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.09.029"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods13010151"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.11.027"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-022-03228-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/M19-2880"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13345"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2024.103117"},{"key":"e_1_3_2_17_2","first-page":"454","article-title":"Effect of Shuwel decoction on enteric nervous system-interstitial cells of cajal-smooth muscle network structure injury in deep muscle nerve Plexus of functional dyspepsia rats","volume":"36","author":"Guo XA","year":"2016","unstructured":"Guo XA, Liu Y, Wang XJ, et al. Effect of Shuwel decoction on enteric nervous system-interstitial cells of cajal-smooth muscle network structure injury in deep muscle nerve Plexus of functional dyspepsia rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 2016; 36: 454\u2013459.","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2653"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01362-4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07389.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326158"},{"key":"e_1_3_2_22_2","first-page":"767","article-title":"Effect of electroacupuncture at \u201cZusanli\u201d (ST 36) on duodenal mast cells, NGF and NTRK1 in rats with functional dyspepsia","volume":"42","author":"Dong JZ","year":"2022","unstructured":"Dong JZ, Rong PJ, Wang XT, et al. Effect of electroacupuncture at \u201cZusanli\u201d (ST 36) on duodenal mast cells, NGF and NTRK1 in rats with functional dyspepsia. Zhongguo Zhen Jiu 2022; 42: 767\u2013772.","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jjns.12602"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0b013e31824c235a"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000504090"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2016-000109"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2286598"},{"key":"e_1_3_2_28_2","first-page":"1416236","article-title":"Acupoint massage therapy alters the composition of gut microbiome in functional constipation patients","volume":"2021","author":"Chen H","year":"2021","unstructured":"Chen H, Tan PS, Li CP, et al. Acupoint massage therapy alters the composition of gut microbiome in functional constipation patients. Evid-Based Compl Alt 2021; 2021: 1416236.","journal-title":"Evid-Based Compl Alt"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303857"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2435-5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000827"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32115-2"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12506"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30469-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-021-00556-6"},{"key":"e_1_3_2_36_2","article-title":"Acupuncture for functional dyspepsia","volume":"2014","author":"Lan L","year":"2014","unstructured":"Lan L, Zeng F, Liu GJ, et al. Acupuncture for functional dyspepsia. Cochrane Db Syst Rev 2014; 2014: CD008487.","journal-title":"Cochrane Db Syst Rev"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.781215"}],"updated-by":[{"DOI":"10.1177\/09287329251392360","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000}}],"container-title":["Technology and Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09287329251363139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09287329251363139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09287329251363139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:26:11Z","timestamp":1777670771000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09287329251363139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":36,"alternative-id":["10.1177\/09287329251363139"],"URL":"https:\/\/doi.org\/10.1177\/09287329251363139","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"article-number":"09287329251363139"}}