{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:55:30Z","timestamp":1777924530299,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study was designed to investigate the mechanism of Circ_0046336 in oral squamous cell carcinoma (OSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The expression pattern of Circ_0046336 and its distribution in OSCC cell lines (SCC-9 and CAL-27) were identified. Fluorescence\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridization was applied to determine the location of Circ_0046336. Circ_0046336 silencing was detected by methylthiazolyldiphenyl-tetrazolium bromide (MTT), flow cytometry and transwell assays. The binding relation between Circ_0046336 and miR-181d-3p or ADAM12 and miR-181d-3p was investigated using bioinformatics and dual luciferase reporter assay. ADAM12 and miR-181d-3p expressions in OSCC cells with Circ_0046336 knockdown were quantified. Rescue assays were carried out, and the expressions of epithelial-mesenchymal transition (EMT)-related proteins were measured via Western blot.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Circ_0046336 was overexpressed and mainly distributed in the cytoplasm of OSCC cells. Circ_0046336 targeted miR-181d-3p and miR-181d-3p targeted ADAM12 in OSCC cells. Circ_0046336 silencing facilitated apoptosis, and suppressed viability, migration and invasion of OSCC cells, while upregulating miR-181d-3p and downregulating ADAM12. MiR-181d-3p deficiency reversed the regulatory role of Circ_0046336 in biological behaviors of OSCC cells. Circ_0046336 silencing promoted E-cadherin expression and inhibited N-cadherin and Vimentin expressions, but such effects were reversed by miR-181d-3p downregulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circ_0046336 acts as a ceRNA to regulate apoptosis, migration, invasion and EMT of OSCC cells via miR-181d-3p\/ADAM12 axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251363708","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:49:21Z","timestamp":1754372961000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A new target for the treatment of oral squamous cell carcinoma: Circ_0046336"],"prefix":"10.1177","author":[{"given":"Jijun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology, Ningbo No.2 Hospital, Ningbo City, Zhejiang Province, China"},{"name":"Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo City, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Ningbo No.2 Hospital, Ningbo City, Zhejiang Province, China"},{"name":"Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo City, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danhua","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Ningbo No.2 Hospital, Ningbo City, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Ningbo No.2 Hospital, Ningbo City, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Ningbo No.2 Hospital, Ningbo City, Zhejiang Province, China"},{"name":"Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo City, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"178","article-title":"The prevalence of squamous cell carcinoma in different sites of oral cavity at our Rural Health Care Centre in Loni, Maharashtra - a retrospective 10-year study","volume":"21","author":"Tandon P","year":"2017","unstructured":"Tandon P, Dadhich A, Saluja H, et\u00a0al. The prevalence of squamous cell carcinoma in different sites of oral cavity at our Rural Health Care Centre in Loni, Maharashtra - a retrospective 10-year study. 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