{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:55:37Z","timestamp":1777924537953,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jilin Province Science and technology development project","award":["No. YDZJ202401017ZYTS"],"award-info":[{"award-number":["No. YDZJ202401017ZYTS"]}]},{"name":"Research project of Guangdong Provincial Bureau of Traditional Chinese Medicine","award":["20223016"],"award-info":[{"award-number":["20223016"]}]},{"name":"Beihua University Graduate Student Innovation Project","award":["Beihuayanchuanghezi [2023]068"],"award-info":[{"award-number":["Beihuayanchuanghezi [2023]068"]}]},{"name":"Beihua University Graduate Student Innovation Project","award":["Beihuayanchuanghezi [2023]069"],"award-info":[{"award-number":["Beihuayanchuanghezi [2023]069"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Schizophrenia (SCZ) pharmacotherapy relies on Western medications with limited efficacy\/significant adverse effects. Baicalin (BA), a purified botanical monomer, shows promise as a safer multitarget antipsychotic candidate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the effect and mechanism of Baicalin on MK-801 induced schizophrenia model mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Behavioral assessments (water maze, open field, dark avoidance, forced swimming tests) evaluated emotional\/cognitive functions in MK-801 induced schizophrenia mice. Histological staining analyzed hippocampal, prefrontal cortical, and striatal morphology. Serum inflammatory markers (NF-\n                      <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                      B, IL-6, IL-1\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      , TNF-\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      ) and oxidative stress indicators (SOD, MDA) were quantified by ELISA, alongside hippocampal neurotransmitter levels (DA, 5-HT, GABA, AChE). This study employed a network pharmacology approach to screen the mechanisms of action of baicalin in the treatment of schizophrenia. Western blotting determined hippocampal PI3K\/Akt\/GSK3\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      pathway protein expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Network pharmacology analysis revealed that baicalin may exert its therapeutic effects in the treatment of schizophrenia through modulation of the PI3K-Akt signaling pathway. Versus model group, BA doses significantly decreased: IL-1\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      , IL-6, GABA, AChE, MDA, TNF-\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      , NF-\n                      <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                      B; open field total distance; forced swimming immobility; dark avoidance errors (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Increased: DA, 5-HT; water maze platform crossings; dark avoidance latency (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Staining confirmed BA reduced cerebral oxidative stress\/neuroinflammation. Western blot showed dose-dependent elevation of p-Akt\/Akt and p-GSK3\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \/GSK3\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      ratios.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Baicalin may improve cognitive impairments in MK801-induced schizophrenia model mice through the PI3K\/Akt\/GSK3\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      signaling pathway, exhibiting anti-neuroinflammatory and neuroprotective effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251412965","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:43:52Z","timestamp":1771307032000},"page":"274-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects and mechanisms of baicalin on MK-801 induced schizophrenia model\u00a0mice"],"prefix":"10.1177","volume":"34","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Basic Medicine College of Beihua University, Jilin, P. 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