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In order to analyse the biomechanical difference between healthy and diseased joints, three-dimensional models of these two wrist conditions were developed from computed tomography images. These images consist of eight carpal bones, five metacarpal bones, the distal radius and ulna. The cartilages were developed based on the shape of the available articulations and ligaments were simulated via mechanical links. The RA model was developed accurately by simulating all ten common criteria of the disease related to the wrist. Results from the finite element (FE) analyses showed that the RA model produced three times higher contact pressure at the articulations compared to the healthy model. Normal physiological load transfer also changed from predominantly through the radial side to an increased load transfer approximately 5% towards the ulnar. Based on an extensive literature search, this is the first ever reported work that simulates the pathological conditions of the rheumatoid arthritis of the wrist joint.<\/jats:p>","DOI":"10.1177\/0954411912445846","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T08:43:53Z","timestamp":1337503433000},"page":"510-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Biomechanical analysis of rheumatoid arthritis of the wrist joint"],"prefix":"10.1177","volume":"226","author":[{"given":"MN","family":"Bajuri","sequence":"first","affiliation":[{"name":"Medical Implant Technology Group, Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Rafiq","family":"Abdul Kadir","sequence":"additional","affiliation":[{"name":"Medical Implant Technology Group, Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iskandar M","family":"Amin","sequence":"additional","affiliation":[{"name":"Orthopaedic Department, Hospital Universiti Sains Malaysia, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"\u00d6chsner","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,5,18]]},"reference":[{"issue":"2","key":"e_1_3_3_2_2","first-page":"89","article-title":"The hand and wrist in rheumatoid arthritis and osteoarthritis","volume":"28","author":"Broadbent MR","year":"2010","unstructured":"Broadbent MR, Hayton MJ. 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