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In this study, the influence of the ageing of the spinal components on cortical shell strain was investigated. A lumbar spinal specimen (L3\u2013L5) was mechanically tested under a quasi-static axial compressive load. Clinical computed tomography images of the same specimen were used to create a corresponding finite element model. The material properties were determined by calibrating the finite element model using the L4 cortical shell strains of the anterior centre measurement site. The remaining experiment data (axial displacement, the intra-discal pressures, L4 cortical shell strain on the lateral measurement site) were used to evaluate the model. The individual ageing process of the six spinal components (cortical shell, cancellous bone, bony endplate, posterior elements, nucleus pulposus and annulus matrix) was simulated by changing their Young\u2019s moduli and Poisson\u2019s ratios, and the effect on cortical shell strain was investigated. Results show that the cortical shell strain is more sensitive to the ageing of the cortical shell and the cancellous bone than to the ageing of the nucleus pulposus, the annulus matrix, and the bony endplates and of the posterior elements. The results can help the clinicians focus on the aspects that mainly influence the vertebral cortex fracture risk factor.<\/jats:p>","DOI":"10.1177\/0954411913501293","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T22:44:01Z","timestamp":1377816241000},"page":"1265-1274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Strain changes on the cortical shell of vertebral bodies due to spine ageing: A parametric study using a finite element model evaluated by strain measurements"],"prefix":"10.1177","volume":"227","author":[{"given":"Yongtao","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Rosenau","sequence":"additional","affiliation":[{"name":"Centre for Endoprosthetics, Sch\u00f6n Klinik Hamburg 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