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In this study, the levels of IL-6 and IL-8 were assessed in different grades of osteoarthritis to determine whether their concentrations in the synovial fluid correlate with specific characteristics of wear particles. This study has found that the size, adhesion and nano-surface roughness of wear particles have medium strong to strong correlations with IL-6 and IL-8. This study provided evidence that the characteristics of wear particles contain valuable information for grading the disease process and the need for further evaluation of the association of properties of wear particles and the inflammatory process.<\/jats:p>","DOI":"10.1177\/0954411914559570","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T02:59:13Z","timestamp":1418266753000},"page":"1176-1182","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigations of wear particles and selected cytokines in human osteoarthritic knee joints"],"prefix":"10.1177","volume":"228","author":[{"given":"Meiling","family":"Wang","sequence":"first","affiliation":[{"name":"School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natkunam","family":"Ketheesan","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunopathogenesis Research Group, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxiao","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"bibr1-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1163\/156856004773121347"},{"key":"bibr2-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.12.011"},{"key":"bibr3-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.11.008"},{"key":"bibr4-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.02.001"},{"key":"bibr5-0954411914559570","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00016"},{"key":"bibr6-0954411914559570","volume-title":"Articular cartilage and knee joint function: basic science and arthroscopy","author":"Ewing J","year":"1990"},{"key":"bibr7-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8400-3"},{"key":"bibr8-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/0043-1648(78)90250-8"},{"key":"bibr9-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.9.978"},{"key":"bibr10-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/j.cap.2006.11.028"},{"key":"bibr11-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1007\/s11249-013-0160-8"},{"key":"bibr12-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1080\/03009740701250785"},{"key":"bibr13-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1126\/science.3131876"},{"key":"bibr14-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1186\/ar4107"},{"key":"bibr15-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.12.013"},{"key":"bibr16-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.03.015"},{"key":"bibr17-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197507000-00024"},{"key":"bibr18-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/j.wear.2006.07.011"},{"key":"bibr19-0954411914559570","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(75)90018-1"},{"key":"bibr20-0954411914559570","unstructured":"ISO 25178-2: 2006. 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