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The aim of the device is to restore the correct functionality of the valve and solve mitral valve regurgitation, that is, a common consequence of chordae tendineae rupture. An analysis of the requirements was carried out and used to design and develop a first functional prototype. The resulting device was able to connect artificial chords at the posterior leaflet of the mitral valve and at the apex of the left ventricle, also allowing the control of the artificial chord length. The ChoRe was tested ex-vivo in bovine hearts. The qualitative assessment of the ChoRe focused on the performance of the device and preliminary evaluation of the procedure time. Results demonstrated that the device is able to create a top and bottom fixation in an average time of 3.45\u2009\u00b1\u20091.44\u2009min. Future improvements will focus on enhancing the connection at the leaflet, as well as the overall functionality, in order to guarantee better control of the artificial chord length. This work shows future potentials for more patient-specific treatments in trans-catheter scenarios for mitral valve repair.<\/jats:p>","DOI":"10.1177\/0954411919848856","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T06:11:21Z","timestamp":1557295881000},"page":"712-722","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["ChoRe: A device for trans-catheter chordae tendineae repair"],"prefix":"10.1177","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-3788","authenticated-orcid":false,"given":"Costanza","family":"Culmone","sequence":"first","affiliation":[{"name":"Bio-Inspired Technology Group (BITE), Department of BioMechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awaz","family":"Ali","sequence":"additional","affiliation":[{"name":"Bio-Inspired Technology Group (BITE), Department of BioMechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Scali","sequence":"additional","affiliation":[{"name":"Bio-Inspired Technology Group (BITE), Department of BioMechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Menciassi","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant\u2019Anna, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Breedveld","sequence":"additional","affiliation":[{"name":"Bio-Inspired Technology Group (BITE), Department of BioMechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"bibr1-0954411919848856","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000115202.33689.2C"},{"key":"bibr2-0954411919848856","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"bibr3-0954411919848856","unstructured":"Betts JG, Desaix P, Johnson E, et al. 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