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On the other hand, surgery and bone marrow sampling, especially in the diagnosis of childhood leukemia, are even more complex and difficult, resulting in increased human error and procedure time decreased patient satisfaction and increased costs. This study investigates the use of neuro-fuzzy and group method of data handling, for the diagnosis of acute leukemia in children based on the complete blood count test. Furthermore, a principal component analysis is applied to increase the accuracy of the diagnosis. The results show that distinguishing between patient and non-patient individuals can easily be done with adaptive neuro-fuzzy inference system, whereas for classifying between the types of diseases themselves, more pre-processing operations such as reduction of features may be needed. The proposed approach may help to distinguish between two types of leukemia including acute lymphoblastic leukemia and acute myeloid leukemia. Based on the sensitivity of the diagnosis, experts can use the proposed algorithm to help identify the disease earlier and lessen the cost.<\/jats:p>","DOI":"10.1177\/0954411920938567","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T05:54:21Z","timestamp":1594101261000},"page":"1051-1069","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Design of an integrated model for diagnosis and classification of pediatric acute leukemia using machine learning"],"prefix":"10.1177","volume":"234","author":[{"given":"Ehsan","family":"Fathi","sequence":"first","affiliation":[{"name":"Faculty of Industrial Engineering, Urmia University of Technology, Urmia, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-666X","authenticated-orcid":false,"given":"Mustafa 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