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Along with the emerging of new materials, tribological issues, especially debris, have become a growing concern for fracture fixation plates. This article for the first time systematically reviews the most recent biomechanical research, with a focus on experimental testing, of those plates within ScienceDirect and PubMed databases. Based on the search criteria, a total of 5449 papers were retrieved, which were then further filtered to exclude nonrelevant, duplicate or non-accessible full article papers. In the end, a total of 83 papers were reviewed. In experimental testing plates, screws and simulated bones or cadaver bones are employed to build a fixation construct in order to test the strength and stability of different plate and screw configurations. The test set-up conditions and conclusions are well documented and summarised here, including fracture gap size, types of bones deployed, as well as the applied load, test speed and test ending criteria. However, research on long term plate usage was very limited. It is also discovered that there is very limited experimental research around the tribological behaviour particularly on the debris\u2019 generation, collection and characterisation. In addition, there is no identified standard studying debris of fracture fixation plate. Therefore, the authors suggested the generation of a suite of tribological testing standards on fracture fixation plate and screws in the aim to answer key questions around the debris from fracture fixation plate of new materials or new design and ultimately to provide an insight on how to reduce the risks of debris-related osteolysis, inflammation and aseptic loosening.<\/jats:p>","DOI":"10.1177\/09544119221108540","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T07:30:28Z","timestamp":1659511828000},"page":"1253-1272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Experimental testing of fracture fixation plates: A review"],"prefix":"10.1177","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-8143","authenticated-orcid":false,"given":"Shiling","family":"Zhang","sequence":"first","affiliation":[{"name":"Aston Institute of Materials Research (AIMR), Aston University, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Invibio Biomaterial Solutions Limited, Hillhouse International, Thornton-Cleveleys, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Brady","sequence":"additional","affiliation":[{"name":"Invibio Biomaterial Solutions Limited, Hillhouse International, Thornton-Cleveleys, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Gambill","sequence":"additional","affiliation":[{"name":"Invibio Biomaterial Solutions Limited, Hillhouse International, Thornton-Cleveleys, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-3400","authenticated-orcid":false,"given":"Kanthan","family":"Theivendran","sequence":"additional","affiliation":[{"name":"Sandwell and West Birmingham Hospital NHS Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subodh","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Sandwell and West Birmingham Hospital NHS Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-3461","authenticated-orcid":false,"given":"John","family":"Swadener","sequence":"additional","affiliation":[{"name":"Aston Institute of Materials Research (AIMR), Aston University, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Junaid","sequence":"additional","affiliation":[{"name":"Aston Institute of Materials Research (AIMR), Aston University, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7925-9589","authenticated-orcid":false,"given":"Laura Jane","family":"Leslie","sequence":"additional","affiliation":[{"name":"Aston Institute of Materials Research (AIMR), Aston University, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"bibr1-09544119221108540","unstructured":"Cunha JP. 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