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For this study, a mathematical model based on free volume theory has been utilized to simulate the diffusion of low molecular weight plant metabolites. The results demonstrate that the mesh size of the crosslinked network, thereby the diffusion coefficient of the natural compound can be computed using the current framework. The proposed model has also been validated using the experimental data. The diffusion period has been observed to vary within a wide range of 3.42\u2009h for Cinnamaldehyde to 49.25\u2009h for Grandinin. An empirical parametric relationship between the diffusion time and molecular weight of both the hydrogels and natural compounds is established. It appears that the reported modeling approach will be clinically useful for improving the design of the sustained drug delivery systems.<\/jats:p>","DOI":"10.1177\/09544119231162772","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T08:16:21Z","timestamp":1679300181000},"page":"542-551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of diffusion of plant metabolites from polyethylene glycol hydrogels using free volume theory"],"prefix":"10.1177","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-8805","authenticated-orcid":false,"given":"Pooja Vardhini","family":"Natesan","sequence":"first","affiliation":[{"name":"Biomedical Engineering Group, Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai, 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