{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:35:45Z","timestamp":1777926945672,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["LH2022H096"],"award-info":[{"award-number":["LH2022H096"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"2022 Annual National Fund Cultivation Project of Jiamusi University","award":["JMSUGPZR2022-001"],"award-info":[{"award-number":["JMSUGPZR2022-001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Proc Inst Mech Eng H"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    In this study, carboxylated carbon nanotube (CNT)-loaded curcumin (CUR) was blended into calcium phosphate cement (CPC) owing to the poor mechanical properties and single function of CPC as a bone-filling material, and CNT-CUR-CPC with improved strength and antitumor properties was obtained. The failure strength, hydrophilicity, in vitro bioactivity, bacteriostatic activity, antitumor activity, and cell safety of CNT-CUR-CPC were evaluated. The experimental results indicated that the failure strength of CNT-CUR-CPC increased from 25.05 to 45.05\u2009MPa ( p\u2009&lt;\u20090.001) and its contact angle decreased from 20.37\u00b0 to 15.27\u00b0 ( p\u2009&lt;\u20090.001) after the CNT-CUR complex was added into CPC at the rate of 5\u2009wt% and blended. Following soaking in simulated body fluid (m-SBF), the main components of CNT-CUR-CPC were hydroxyapatite (HA) and carbonate hydroxyapatite (HCA). The incorporation of CNT-CUR was beneficial for the deposition of PO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>3\u2212<\/jats:sup>\n                    and CO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    , and it promoted the crystallization of HA and HCA. For CNT-CUR-CPC, the inhibition zone diameter on Staphylococcus aureus was 10.2\u2009\u00b1\u20091.02\u2009mm ( p\u2009&lt;\u20090.001) and it exhibited moderate sensitivity, whereas the inhibition zone diameter on Escherichia coli was 8.3\u2009\u00b1\u20090.23\u2009mm ( p\u2009&lt;\u20090.001) and it exhibited low sensitivity. When compared with the CPC, the cell proliferation rate (RGR %) of the CNT-CUR-CPC decreased by 7.73% ( p\u2009&gt;\u20090.05) at 24\u2009h, 17.89% ( p\u2009&lt;\u20090.05) at 48\u2009h, and 24.43% ( p\u2009&lt;\u20090.001) at 72\u2009h when MG63 cells were cultured on it. In particular, after the MG63 cells were cultured with the CNT-CUR-CPC for 48\u2009h, the number of newly proliferating MG63 cells was significantly reduced, and their growth and adhesion on the surface of the CNT-CUR-CPC were inhibited when compared with the CPC. When 3T3-E1 cells were exposed to the m-SBF immersion solution of CNT-CUR-CPC, the cell proliferation rate (RGR %) was \u226580% ( p\u2009&gt;\u20090.05) and the cytotoxicity grade was 0\u20131. The 3T3-E1 cells were cultured with the m-SBF soaking solution of CNT-CUR-CPC for 24\u2009h, and no significant changes in cell morphology or cytotoxicity were observed. After the 3T3-E1 cells were cultured on CNT-CUR-CPC for 48\u2009h, they could stick to and grow on its surface without adverse reactions. CNT-CUR-CPC had a hemolysis rate of 4.3% ( p\u2009&gt;\u20090.05) and did not result in hemolysis and hemagglutination. The obtained CNT-CUR-CPC scaffold material exhibited effective antibacterial activity and cell safety, and could achieve a certain antitumor effect, which has a wide application potential in bone tissue engineering.\n                  <\/jats:p>","DOI":"10.1177\/09544119231207614","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T01:21:40Z","timestamp":1701307300000},"page":"1348-1365","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel bone cement based on calcium phosphate composited CNT curcumin with improved strength and antitumor properties"],"prefix":"10.1177","volume":"237","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[{"name":"Jiamusi University, Jiamusi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiamusi University, Jiamusi, 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