{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:47:39Z","timestamp":1783334859354,"version":"3.54.6"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sagepub.com\/licence-information-for-chorus"}],"funder":[{"DOI":"10.13039\/100000147","name":"Division of Civil, Mechanical and Manufacturing Innovation","doi-asserted-by":"publisher","award":["2034964"],"award-info":[{"award-number":["2034964"]}],"id":[{"id":"10.13039\/100000147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Proc Inst Mech Eng H"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Due to its ability to induce heterogenous, patient-specific damage in pulmonary alveoli and capillaries, COVID-19 poses challenges in defining a uniform profile to elucidate infection across all patients. Computational models that integrate changes in ventilation and perfusion with heterogeneous damage profiles offer valuable insights into the impact of COVID-19 on pulmonary health. This study aims to develop an in silico hypothesis-testing platform specifically focused on studying microvascular pulmonary perfusion in COVID-19-infected lungs. Through this platform, we explore the effects of various acinar-level pulmonary perfusion abnormalities on global lung function. Our modelling approach simulates changes in pulmonary perfusion and the resulting mismatch of ventilation and perfusion in COVID-19-afflicted lungs. Using this coupled modelling platform, we conducted multiple simulations to assess different scenarios of perfusion abnormalities in COVID-19-infected lungs. The simulation results showed an overall decrease in ventilation-perfusion (V\/Q) ratio with inclusion of various types of perfusion abnormalities such as hypoperfusion with and without microangiopathy. This model serves as a foundation for comprehending and comparing the spectrum of findings associated with COVID-19 in the lung, paving the way for patient-specific modelling of microscale lung damage in emerging pulmonary pathologies like COVID-19.<\/jats:p>","DOI":"10.1177\/09544119241241550","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:31:34Z","timestamp":1712050294000},"page":"562-574","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Physics-based in silico modelling of microvascular pulmonary perfusion in COVID-19"],"prefix":"10.1177","volume":"238","author":[{"given":"Elizabeth","family":"Dimbath","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shea","family":"Middleton","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Sean","family":"Peach","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Brody School of Medicine, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Brody School of Medicine, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"George","sequence":"additional","affiliation":[{"name":"Department of Engineering, College of Engineering and Technology, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisandra","family":"de Castro Br\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-8407","authenticated-orcid":false,"given":"Alex","family":"Vadati","sequence":"additional","affiliation":[{"name":"Department of Engineering, College of Engineering and Technology, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"bibr1-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119341"},{"key":"bibr2-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0817LE"},{"key":"bibr3-09544119241241550","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.21.15245-9"},{"key":"bibr4-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00871.2020"},{"key":"bibr5-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252478"},{"key":"bibr6-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.26.3.397"},{"key":"bibr7-09544119241241550","first-page":"999","volume":"15","author":"Weibel E","year":"1979","journal-title":"Bull Eur Physiopathol Respir"},{"key":"bibr8-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1115\/1.4025092"},{"key":"bibr9-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00229.2013"},{"key":"bibr10-09544119241241550","volume-title":"West\u2019s respiratory physiology","author":"West JB","year":"2020"},{"key":"bibr11-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1965.20.2.175"},{"key":"bibr12-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.2.545"},{"key":"bibr13-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.5.1711"},{"key":"bibr14-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1969.26.4.472"},{"key":"bibr15-09544119241241550","volume-title":"Biomechanics: circulation","author":"Fung Y-C","year":"2013"},{"key":"bibr16-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2016.08.010"},{"key":"bibr17-09544119241241550","volume-title":"Reduced dimensional modeling of the entire human lung","author":"Ismail M","year":"2014"},{"key":"bibr18-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1080\/21681163.2015.1023358"},{"key":"bibr19-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01177.2009"},{"key":"bibr20-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105513"},{"key":"bibr21-09544119241241550","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01848"},{"key":"bibr22-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144105"},{"key":"bibr23-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00775.2010"},{"key":"bibr24-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092200410"},{"key":"bibr25-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.4.1501"},{"key":"bibr26-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1115\/IMECE2002-33525"},{"key":"bibr27-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1017\/S1446181118000111"},{"key":"bibr28-09544119241241550","first-page":"S87","volume-title":"Microvascular research","author":"Sobin S","year":"1979"},{"key":"bibr29-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2787"},{"key":"bibr30-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04920-w"},{"key":"bibr31-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"bibr32-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153228"},{"key":"bibr33-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03594-6"},{"key":"bibr34-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202006-2598LE"},{"key":"bibr35-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18672-6"},{"key":"bibr36-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01033.2004"},{"key":"bibr37-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2012.11.031"},{"key":"bibr38-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-017-0071-6"},{"key":"bibr39-09544119241241550","doi-asserted-by":"publisher","DOI":"10.36628\/ijhf.2020.0047"},{"key":"bibr40-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.06.020"},{"key":"bibr41-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104505"},{"key":"bibr42-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22527"},{"key":"bibr43-09544119241241550","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008861"},{"key":"bibr44-09544119241241550","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.197116"},{"key":"bibr45-09544119241241550","volume-title":"StatPearls [Internet]","author":"Bhutta BS","year":"2022"}],"container-title":["Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09544119241241550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09544119241241550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09544119241241550","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09544119241241550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:29:02Z","timestamp":1777674542000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09544119241241550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/09544119241241550"],"URL":"https:\/\/doi.org\/10.1177\/09544119241241550","relation":{},"ISSN":["0954-4119","2041-3033"],"issn-type":[{"value":"0954-4119","type":"print"},{"value":"2041-3033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]}}}