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There are concerns that cross-links may impair adjuvant treatments, such as radiotherapy and proton beam therapy. The aim of this study was to assess the biomechanical effects of cross-link stabilisation for a growing tumour in order to provide recommendations on the use and placement of the cross-link. A finite element (FE) model of a fixation device was developed. The device was inserted virtually into a FE model of the lumbar spine (L1\u2013S1) between L2 and L4. Tumour deposit of either 1.3%, 10.1%, 38.3%, 71.5% and 92.1% of the vertebral body was simulated. A 1000\u2009N compressive, a 10\u00b0 lateral bending and a 7.5\u2009Nm torsional load were simulated on the top of L1. Results indicate that the stabilisation is capable of reducing the stress of the L3 lumbar spine under torsion with a growing tumour. However, compressive loading is concentrated in the L3 anterior vertebra when the tumour volume was greater than 10.1% of the vertebra volume. 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The position of the cross-link does affect the ability of stabilisation to reduce concentrated stress of both vertebrae and screws, which indicates that the position of the cross-link should be considered in clinical surgery to refine the stress concentration, spinal stability and structural stiffness, without compromising adjuvant treatments.<\/jats:p>","DOI":"10.1177\/09544119251348279","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T02:41:57Z","timestamp":1751942517000},"page":"607-623","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A finite element study of the effect of cross-link stabilisation in a lumbar spine tumour model"],"prefix":"10.1177","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5488-8619","authenticated-orcid":false,"given":"Juntong","family":"Lai","sequence":"first","affiliation":[{"name":"School of Mechanical, Aerospace and Civil Engineering, University of Sheffield, Sheffield, UK"},{"name":"Insigneo Institute for Insilico Medicine, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Breakwell","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-6006","authenticated-orcid":false,"given":"Damien","family":"Lacroix","sequence":"additional","affiliation":[{"name":"School of Mechanical, Aerospace and Civil Engineering, University of Sheffield, Sheffield, UK"},{"name":"Insigneo Institute for Insilico Medicine, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8237.151587"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v7.i2.109"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199512151-00011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-3947(02)00083-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx567"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678909154177"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2018.12.04"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181e16ae2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.12269"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i3.263"},{"key":"e_1_3_3_13_2","first-page":"94","article-title":"Diagnosis and management of metastatic spine disease: a review","volume":"13","author":"Sciubba DM","year":"2010","unstructured":"Sciubba DM, Petteys RJ, Dekutoski MB, et al. 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