{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:42:08Z","timestamp":1779273728276,"version":"3.51.4"},"reference-count":74,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR082130"],"award-info":[{"award-number":["R21AR082130"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Proc Inst Mech Eng H"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    The development of innovative small bone replacements for the human wrist has been partially limited by the lack of a suitable preclinical animal model. This study explores the feasibility of using the Yucatan minipig (YMP) as a preclinical model for small bone replacement. Implants for the radial carpal bone (RCB), homologous to the human scaphoid, were developed for a pilot in vivo animal study. RCB size (volume, bounding box dimensions) was quantified (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200935), and relationships between animal age, weight, and RCB volume were investigated. Bounding box dimensions were also analyzed relative to RCB volume. A mean-shaped RCB model was generated using ShapeWorks Studio and scaled to create a set of implants. These implants were evaluated in a pilot in vivo study, where the distances between the explanted bone surface and both the predicted and surgeon-selected implant surfaces were recorded for each animal. Predicted implant distances (0.8\u2009\u00b1\u20090.2\u2009mm), were larger (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) than surgeon-selected implant distances (0.4\u2009\u00b1\u20090.1\u2009mm) in three animals. In one animal, the predicted implant distances (0.3\u2009\u00b1\u20090.2\u2009mm) were smaller (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) than the surgeon-selected implant distances (0.5\u2009\u00b1\u20090.3\u2009mm). The set of implants generated provided the surgeon with options suitable for the range of animals in the in vivo study. This study presents a novel approach to generating small bone replacements by scaling a mean-shaped bone in a porcine model and further evaluates the YMP as a preclinical model for small bone replacement in the human wrist.\n                  <\/jats:p>","DOI":"10.1177\/09544119251355382","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:57:26Z","timestamp":1753426646000},"page":"755-765","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of small bone implants using a mean shape bone in a porcine model for carpal bone replacement"],"prefix":"10.1177","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-0877","authenticated-orcid":false,"given":"Quianna M","family":"Vaughan","sequence":"first","affiliation":[{"name":"Institute for Biology, Engineering, and Medicine, Brown University, Providence, RI, USA"},{"name":"Department of Orthopedics, The Warren Alpert Medical School of Brown University and Brown University Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Warren Alpert Medical School of Brown University and Brown University Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Warren Alpert Medical School of Brown University and Brown University Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Akelman","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Warren Alpert Medical School of Brown University and Brown University Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J","family":"Crisco","sequence":"additional","affiliation":[{"name":"Institute for Biology, Engineering, and Medicine, Brown University, Providence, RI, USA"},{"name":"Department of Orthopedics, The Warren Alpert Medical School of Brown University and Brown University Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753193415616939"},{"key":"e_1_3_3_3_2","first-page":"488","volume-title":"Green\u2019s operative hand surgery","author":"Wolfe SW","year":"2022","unstructured":"Wolfe SW, Kakar S. 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