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The device comprises two parts that fit together, with a suture inserted between them. Ultrasonic welding is then used to secure the suture by welding the two parts together. The device was manufactured from three biodegradable polymers: Poly(L-lactide-co-D,L-lactide) [PLDLA]; Poly(L-lactide-co-glycolide) [PLGA]; Poly(L-lactide) [PLLA]. All devices were degraded through immersion in phosphate buffer solution at a temperature of 37\u00b0C\u2009\u00b1\u20092\u00b0C. Knotted sutures on their own were also subject to degradation testing. The devices and knotted sutures were mechanically tested at week zero and after 1, 3 and 6\u2009weeks of degradation. Mechanically testing was undertaken to measure the pull-out strength of sutures from the device. PLGA is not suitable for the device, where a significant reduction in failure force was seen after 3\u2009weeks of degradation. By week 6 the mean failure force (\u00b1SD) for PLGA was 74.9\u2009\u00b1\u200923.4\u2009N, which was significantly less than the use of a suture knot on its own, with a mean failure force of 153.2\u2009\u00b1\u200937.2\u2009N. PLDLA and PLLA were found to be promising materials, with only a small reduction in mean failure force after 6\u2009weeks of degradation. At week 6 there was no significant difference between the mean failure force of PLDLA, PLLA or the suture knot, with mean failure forces of 152.6\u2009\u00b1\u200915.0, 128.8\u2009\u00b1\u200935.0 and 153.2\u2009\u00b1\u200937.2\u2009N, respectively.<\/jats:p>","DOI":"10.1177\/09544119251405597","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:59:42Z","timestamp":1765781982000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Degradation of an ultrasonically welded device for surgical suture holding"],"prefix":"10.1177","volume":"240","author":[{"given":"Joseph P.","family":"Crolla","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, School of Engineering, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliott","family":"Farrell","sequence":"additional","affiliation":[{"name":"OsteoWeld Surgical Ltd, Worcestershire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-6513","authenticated-orcid":false,"given":"Lauren E. 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