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HI-244 effectively inhibited the replication of HIV-1 strain HTLV<jats:sub>IIIB<\/jats:sub> in human peripheral blood mononuclear cells with an IC<jats:sub>50<\/jats:sub> value of 0.007 \u03bcM, which is equal to the IC<jats:sub>50<\/jats:sub> value of trovirdine. Notably, HI-244 was 20 times more effective than trovirdine against the multidrug-resistant HIV-1 strain RT-MDR with a V106A mutation (as well as additional mutations involving the RT residues 74 V, 41L and 215Y) and seven times more potent than trovirdine against the NNRTI- resistant HIV-1 strain A17 with a Y181C mutation. <\/jats:p>","DOI":"10.1177\/095632020001100205","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T17:01:37Z","timestamp":1426525297000},"page":"135-140","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["N-[2-(4-Methylphenyl)Ethyl]-N\u2032-[2-(5-Bromopyridyl)]-Thiourea as a Potent Inhibitor of NNRTI-Resistant and Multidrug-Resistant Human Immunodeficiency Virus Type 1"],"prefix":"10.1177","volume":"11","author":[{"given":"Fatih M","family":"Uckun","sequence":"first","affiliation":[{"name":"Drug Discovery Program, and Departments of 2Virology, 3Structural Biology and 4Chemistry, Parker Hughes Institute, St Paul, Minn., USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Pendergrass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Drug Discovery Program, and Departments of 2Virology, 3Structural Biology and 4Chemistry, Parker Hughes Institute, St Paul, Minn., USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Tuel-Ahlgren","sequence":"additional","affiliation":[{"name":"Drug Discovery Program, and Departments of 2Virology, 3Structural Biology and 4Chemistry, Parker Hughes Institute, St Paul, Minn., USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TK","family":"Venkatachalam","sequence":"additional","affiliation":[{"name":"Drug Discovery Program, and Departments of 2Virology, 3Structural Biology and 4Chemistry, Parker Hughes Institute, St Paul, Minn., USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"volume-title":"InsightII, computer program","year":"1996","author":"Anonymous","key":"bibr1-095632020001100205"},{"key":"bibr2-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1021\/jm00025a010"},{"key":"bibr3-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1007\/BF00126217"},{"key":"bibr4-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1007\/BF00126743"},{"key":"bibr5-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1126\/science.6879170"},{"key":"bibr6-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0698"},{"key":"bibr7-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.4.835"},{"key":"bibr8-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1038\/365451a0"},{"key":"bibr9-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00235-8"},{"key":"bibr10-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00384-9"},{"key":"bibr11-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199701001-00001"},{"key":"bibr12-095632020001100205","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.11241"},{"key":"bibr13-095632020001100205","doi-asserted-by":"crossref","unstructured":"Sudbeck EA, Mao C, Vig R, Venkatachalam TK, Tuel-Ahlgren L & Uckun FM (1998) Structure-based design of novel dihydroalkoxy-benzyloxopyrimidine (DABO) derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. 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