{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:04:01Z","timestamp":1790712241268,"version":"4.1.0"},"reference-count":195,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antivir Chem Chemother"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p> In 1997\u20131998, the pharmacological cyclin-dependent kinase (CDK) inhibitors (PCIs) were independently discovered to inhibit replication of human cytomegalovirus, herpes simplex virus type 1 and HIV-1. The results from small clinical trials against cancer were then suggesting that PCIs could be safe enough to be used clinically. It was thus hypothesized that PCIs could have the potential to be developed as novel antivirals targeting cellular proteins. Consequently, Antiviral Chemistry &amp; Chemotherapy published in 2001 the first review on the potential of CDKs, and cellular proteins in general, as potential targets for antivirals. The viral functions inhibited by PCIs, or their cellular targets, were then just starting to be characterized. The antiviral spectrum of PCIs and their effects on viral disease were still mostly untested. Even their actual specificity was not yet completely characterized. In addition, cellular proteins were not accepted as valid targets for antivirals. Significant progress has been made in the last 5 years in understanding the antiviral activities of PCIs and the potential roles of cellular proteins in general as targets for antivirals. The first clinical trials of the antiviral activities of PCIs and other inhibitors of cellular protein kinases have now been scheduled. Herein, we review the progress made since the publication of the first review on PCIs as potential antiviral drugs and on CDKs, and cellular proteins in general, as potential targets for antiviral drugs. We also highlight the major issues that still need to be addressed before PCIs or other drugs targeting cellular proteins can be developed as clinical antivirals. <\/jats:p>","DOI":"10.1177\/095632020601700601","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T17:01:37Z","timestamp":1426525297000},"page":"293-320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":69,"title":["Five Years of Progress on Cyclin-Dependent Kinases and other Cellular Proteins as Potential Targets for Antiviral Drugs"],"prefix":"10.1177","volume":"17","author":[{"given":"Luis M","family":"Schang","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille R","family":"St. Vincent","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J","family":"Lacasse","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"bibr1-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406435200"},{"key":"bibr2-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103408200"},{"key":"bibr3-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703870"},{"key":"bibr4-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.01.002"},{"key":"bibr5-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500806200"},{"key":"bibr6-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20981"},{"key":"bibr7-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021535"},{"key":"bibr8-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(98)80086-6"},{"key":"bibr9-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.9.2217"},{"key":"bibr10-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvj022"},{"key":"bibr11-095632020601700601","first-page":"317","volume":"25","author":"Bayes M","year":"2003","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"bibr12-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.09.024"},{"key":"bibr13-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.16.5417-5425.2001"},{"key":"bibr14-095632020601700601","first-page":"2419","volume":"60","author":"Bible KC","year":"2000","journal-title":"Cancer Research"},{"key":"bibr15-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.1998.00340.x"},{"key":"bibr16-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8489"},{"key":"bibr17-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl027"},{"key":"bibr18-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.62.3.866-874.1988"},{"key":"bibr19-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003400948"},{"key":"bibr20-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2005.08.008"},{"key":"bibr21-095632020601700601","first-page":"2973","volume":"56","author":"Carlson BA","year":"1996","journal-title":"Cancer Research"},{"key":"bibr22-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/128.5.658"},{"key":"bibr23-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000446200"},{"key":"bibr24-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102306200"},{"key":"bibr25-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.3.831-841.2003"},{"key":"bibr26-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2005.04.007"},{"key":"bibr27-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.7.3378-3386.2004"},{"key":"bibr28-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/nsb842"},{"key":"bibr29-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00266-8"},{"key":"bibr30-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2735"},{"key":"bibr31-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.0518a.x"},{"key":"bibr32-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00089-3"},{"key":"bibr33-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2174\/1570162033485339"},{"key":"bibr34-095632020601700601","first-page":"578","volume":"5","author":"de Rudder J","year":"1965","journal-title":"Antimicrobial Agents & Chemotherapy"},{"key":"bibr35-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2217\/17460794.1.4.509"},{"key":"bibr36-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.17.9352-9365.2004"},{"key":"bibr37-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363190-00002"},{"key":"bibr38-095632020601700601","first-page":"273","volume":"3","author":"Drees M","year":"1997","journal-title":"Clinical Cancer Research"},{"key":"bibr39-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208012"},{"key":"bibr40-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.170093297"},{"key":"bibr41-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-3-549"},{"key":"bibr42-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1068"},{"key":"bibr43-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004626200"},{"key":"bibr44-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.12.6.955"},{"key":"bibr45-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.14.4.457"},{"key":"bibr46-095632020601700601","first-page":"235","volume":"5","author":"Fisher P","year":"2003","journal-title":"Progress in Cell Cycle Research"},{"key":"bibr47-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1177\/095632020301400406"},{"key":"bibr48-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7208"},{"key":"bibr49-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(01)01808-6"},{"key":"bibr50-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-1-10"},{"key":"bibr51-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000124672.41036.F4"},{"key":"bibr52-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.11.2818"},{"key":"bibr53-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.62.11.4104-4112.1988"},{"key":"bibr54-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.6.4193-4198.1997"},{"key":"bibr55-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5376.533"},{"key":"bibr56-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20000701)21:12<2522::AID-ELPS2522>3.0.CO;2-A"},{"key":"bibr57-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2108fje"},{"key":"bibr58-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.24.13582-13590.2004"},{"key":"bibr59-095632020601700601","first-page":"1311","volume":"5","author":"Guzi T","year":"2004","journal-title":"Current Opinion in Investigational Drugs"},{"key":"bibr60-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503312200"},{"key":"bibr61-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.19.10566-10574.2003"},{"key":"bibr62-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000194805.74293.11"},{"key":"bibr63-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/9035"},{"key":"bibr64-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690687"},{"key":"bibr65-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210057200"},{"key":"bibr66-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2000.tb00929.x"},{"key":"bibr67-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050504297"},{"key":"bibr68-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.10.8843-8847.1999"},{"key":"bibr69-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.2220"},{"key":"bibr70-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1962.00960030239015"},{"key":"bibr71-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1962.00960020583012"},{"key":"bibr72-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400343200"},{"key":"bibr73-095632020601700601","first-page":"S68","volume":"10","author":"Kitrinos K","year":"2005","journal-title":"Antiviral Therapy"},{"key":"bibr74-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(00)00124-1"},{"key":"bibr75-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)02071-0"},{"key":"bibr76-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01144-9"},{"key":"bibr77-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.079"},{"key":"bibr78-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.09.057"},{"key":"bibr79-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-1-42"},{"key":"bibr80-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(03)00033-2"},{"key":"bibr81-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.1.104-115.2004"},{"key":"bibr82-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-S1-S5"},{"key":"bibr83-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2217\/14750708.2.1.77"},{"key":"bibr84-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.2.624-635.2001"},{"key":"bibr85-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"bibr86-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)80800-0"},{"key":"bibr87-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002466200"},{"key":"bibr88-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.3.1984-1991.1997"},{"key":"bibr89-095632020601700601","first-page":"3992","volume":"55","author":"Li S","year":"1995","journal-title":"Cancer Research"},{"key":"bibr90-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.8.3188-3197.2004"},{"key":"bibr91-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-20"},{"key":"bibr92-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1742"},{"key":"bibr93-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.382"},{"key":"bibr94-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.08.020"},{"key":"bibr95-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.08.002"},{"key":"bibr96-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.20.2633"},{"key":"bibr97-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.3.654"},{"key":"bibr98-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075762"},{"key":"bibr99-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-27-1-25"},{"key":"bibr100-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1809-9_29"},{"key":"bibr101-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(96)10034-9"},{"key":"bibr102-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.t01-2-00527.x"},{"key":"bibr103-095632020601700601","volume-title":"Indirubin, the red shade of indigo","author":"Meijer L","year":"2006"},{"key":"bibr104-095632020601700601","volume-title":"Cell cycle regulators as therapeutic targets","author":"Meijer L","year":"2003"},{"key":"bibr105-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(97)83011-X"},{"key":"bibr106-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1021\/ar0201198"},{"key":"bibr107-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05360.x"},{"key":"bibr108-095632020601700601","first-page":"751","volume":"18","author":"Mgbonyebi OP","year":"1998","journal-title":"Anticancer Research"},{"key":"bibr109-095632020601700601","first-page":"1903","volume":"59","author":"Mgbonyebi OP","year":"1999","journal-title":"Cancer Research"},{"key":"bibr110-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1021\/jm0305568"},{"key":"bibr111-095632020601700601","first-page":"537","volume":"8","author":"Moffat J","year":"2003","journal-title":"Cellular & Molecular Biology Letters"},{"key":"bibr112-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.2.1039-1043.2001"},{"key":"bibr113-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/35057033"},{"key":"bibr114-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200403260-00004"},{"key":"bibr115-095632020601700601","first-page":"649","volume":"364","author":"Nekhai S","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"bibr116-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg175"},{"key":"bibr117-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12122827"},{"key":"bibr118-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.2.619-632.2002"},{"key":"bibr119-095632020601700601","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1158\/1535-7163.125.4.1","volume":"4","author":"Nutley BP","year":"2005","journal-title":"Molecular Cancer Therapeutics"},{"key":"bibr120-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004485200"},{"key":"bibr121-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1092"},{"key":"bibr122-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/ng1232"},{"key":"bibr123-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1177\/0091270002250615"},{"key":"bibr124-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9243"},{"key":"bibr125-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3661"},{"key":"bibr126-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2507"},{"key":"bibr127-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400639"},{"key":"bibr128-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1251\/bpo86"},{"key":"bibr129-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119793"},{"key":"bibr130-095632020601700601","first-page":"33","volume":"12","author":"Pisell TL","year":"2001","journal-title":"Antiviral Chemistry & Chemotherapy"},{"key":"bibr131-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90501-2"},{"key":"bibr132-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043382422"},{"key":"bibr133-095632020601700601","first-page":"428","volume":"59","author":"Raina A","year":"1981","journal-title":"Medical Biology"},{"key":"bibr134-095632020601700601","first-page":"278","volume":"6","author":"Ramondetta L","year":"2000","journal-title":"Clinical Cancer Research"},{"key":"bibr135-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/8751"},{"key":"bibr136-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2264"},{"key":"bibr137-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/nm1265"},{"key":"bibr138-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313852200"},{"key":"bibr139-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a004076"},{"key":"bibr140-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/47520"},{"key":"bibr141-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2174\/1568011033353605"},{"key":"bibr142-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2003.09.004"},{"key":"bibr143-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.20.11219-11232.2004"},{"key":"bibr144-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02656-05"},{"key":"bibr145-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(03)00792-3"},{"key":"bibr146-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2741\/1871"},{"key":"bibr147-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00062-X"},{"key":"bibr148-095632020601700601","first-page":"157","volume":"12","author":"Schang LM","year":"2001","journal-title":"Antiviral Chemistry & Chemotherapy"},{"key":"bibr149-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf227"},{"key":"bibr150-095632020601700601","first-page":"103","volume":"5","author":"Schang LM","year":"2003","journal-title":"Progress in Cell Cycle Research"},{"key":"bibr151-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2003.11.024"},{"key":"bibr152-095632020601700601","first-page":"29","volume":"5","author":"Schang LM","year":"2005","journal-title":"Current DrugTtargets \u2014 Infectious Diseases"},{"key":"bibr153-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.3.2.145"},{"key":"bibr154-095632020601700601","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776361174"},{"key":"bibr155-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.15.7874-7882.2002"},{"key":"bibr156-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.15.7724-7735.2002"},{"key":"bibr157-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.5626-5637.1998"},{"key":"bibr158-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.2161-2172.1999"},{"key":"bibr159-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.5.2107-2120.2000"},{"key":"bibr160-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00773-5"},{"key":"bibr161-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1021\/jm0108348"},{"key":"bibr162-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.7.1985"},{"key":"bibr163-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.7-suppl_3-12"},{"key":"bibr164-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.9.2986"},{"key":"bibr165-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.5.376"},{"key":"bibr166-095632020601700601","first-page":"1590","volume":"7","author":"Shapiro GI","year":"2001","journal-title":"Clinical Cancer Research"},{"key":"bibr167-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(99)00004-2"},{"key":"bibr168-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3349"},{"key":"bibr169-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.6.436"},{"key":"bibr170-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.2.371"},{"key":"bibr171-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/36606"},{"key":"bibr172-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.21.11615-11621.2004"},{"key":"bibr173-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.24.15477-15493.2005"},{"key":"bibr174-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500805200"},{"key":"bibr175-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.6.2853-2862.2004"},{"key":"bibr176-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-002-0527-2"},{"key":"bibr177-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1002\/med.1021"},{"key":"bibr178-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012519099"},{"key":"bibr179-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.6.4983-4990.1999"},{"key":"bibr180-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)90867-2"},{"key":"bibr181-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.6.5110-5122.1999"},{"key":"bibr182-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.16.7451-7461.2000"},{"key":"bibr183-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058040"},{"key":"bibr184-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.00771.x"},{"key":"bibr185-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.10.091"},{"key":"bibr186-095632020601700601","first-page":"6068","volume":"59","author":"Waheed I","year":"1999","journal-title":"Cancer Research"},{"key":"bibr187-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.16.7266-7279.2001"},{"key":"bibr188-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016555821581"},{"key":"bibr189-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-0110"},{"key":"bibr190-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.06.044"},{"key":"bibr191-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.8.636"},{"key":"bibr192-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523220"},{"key":"bibr193-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.2.1320-1330.1999"},{"key":"bibr194-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1038\/nm1047"},{"key":"bibr195-095632020601700601","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.24.13522-13533.2004"}],"container-title":["Antiviral Chemistry and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095632020601700601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095632020601700601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T09:33:19Z","timestamp":1725355999000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/095632020601700601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":195,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1177\/095632020601700601"],"URL":"https:\/\/doi.org\/10.1177\/095632020601700601","relation":{},"ISSN":["0956-3202","2040-2066"],"issn-type":[{"value":"0956-3202","type":"print"},{"value":"2040-2066","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}