{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:22:17Z","timestamp":1789867337047,"version":"4.0.1"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antivir Chem Chemother"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p> We designed and synthesized novel 2,3-disubstituted quinazolin-4(3 H)-ones by microwave technique and characterized them by spectral analysis. Synthesized compounds were screened for cytotoxicity and for antiviral activity against influenza A (H1N1, H3N2 and H5N1), severe acute respiratory syndrome corona, dengue, yellow fever, Venezuelan equine encephalitis (VEE), Rift Valley fever, and Tacaribe viruses in cell culture. A neutral red uptake assay was used to determine 50% virus-inhibitory concentrations (EC<jats:sub>50<\/jats:sub>) of test compounds and their 50% cytotoxicity concentration (CC<jats:sub>50<\/jats:sub>) in uninfected Madin-Darby canine kidney, Vero, and Vero 76 cells; selectivity indices (ratio of CC<jats:sub>50<\/jats:sub> to EC<jats:sub>50<\/jats:sub>) were derived from the data. The compound 4-(6,8-dibromo-4-oxo-2-phenyl quinazolin-3(4 H)-yl)-N-(4,5-dimethyloxazol-2yl) benzenesulphonamide 15 inhibited the replication of avian influenza (H5N1) virus (EC<jats:sub>50<\/jats:sub>=8.4 \u00b5g\/ml, CC<jats:sub>50<\/jats:sub>&gt;100 \u00b5g\/ml, SI&gt;11.9) as did 4-(6-bromo-4oxo-2phenylquinazolin-3(4 H)-yl) benzene]sulphonamide 5 (EC<jats:sub>50<\/jats:sub>=3 \u00b5g\/ml, CC<jats:sub>50<\/jats:sub>=32 \u00b5g\/ml, SI=11). Compound 5 was also moderately active against VEE and Tacaribe viruses. The methodology described in this report is applicable for rapid synthesis of many compounds with potential antiviral properties. <\/jats:p>","DOI":"10.1177\/095632020701800506","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T17:01:37Z","timestamp":1426525297000},"page":"301-305","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Novel 3-sulphonamido-quinazolin-4(3<i>H<\/i>)-One Derivatives: Microwave-Assisted Synthesis and Evaluation of Antiviral Activities against Respiratory and Biodefense Viruses"],"prefix":"10.1177","volume":"18","author":[{"given":"Periyasamy","family":"Selvam","sequence":"first","affiliation":[{"name":"Arulmigu Kalasalingam College of Pharmacy, Krishnankoil-626190, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulchamy","family":"Vijayalakshimi","sequence":"additional","affiliation":[{"name":"Arulmigu Kalasalingam College of Pharmacy, Krishnankoil-626190, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald F","family":"Smee","sequence":"additional","affiliation":[{"name":"Institute for Antiviral Research, Utah State University, Logan, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian B","family":"Gowen","sequence":"additional","affiliation":[{"name":"Institute for Antiviral Research, Utah State University, Logan, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin G","family":"Julander","sequence":"additional","affiliation":[{"name":"Institute for Antiviral Research, Utah State University, Logan, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig W","family":"Day","sequence":"additional","affiliation":[{"name":"Institute for Antiviral Research, Utah State University, Logan, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale L","family":"Barnard","sequence":"additional","affiliation":[{"name":"Institute for Antiviral Research, Utah State University, Logan, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"bibr1-095632020701800506","first-page":"433","volume":"66","author":"Alagarsamy V","year":"2000","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"bibr2-095632020701800506","first-page":"433","volume":"62","author":"Alagarsamy V","year":"2000","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"bibr3-095632020701800506","first-page":"1280","volume":"36","author":"Desai NC","year":"1998","journal-title":"Indian Journal of Experimental Biology"},{"key":"bibr4-095632020701800506","first-page":"1111","volume":"17","author":"Girija K","year":"2005","journal-title":"Asian Journal of 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