{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:36:09Z","timestamp":1777926969705,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>The aetiology of hepatic dysfunction in patients with HIV infection is multifactorial. Re-activation of hepatitis C infection, drug toxicity, and opportunistic infections are all potential causes. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy for the treatment of HIV infection. It is associated with a significant incidence of hepatotoxicity, usually occurring in the initial month of therapy. We report the case of a 49-year-old man who developed NVP-induced prolonged hepatotoxicity 5 months after commencing antiretroviral therapy.<\/jats:p>","DOI":"10.1177\/095646240001100511","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T18:29:26Z","timestamp":1484677766000},"page":"336-337","source":"Crossref","is-referenced-by-count":11,"title":["Late Onset Hepatitis and Prolonged Deterioration in Hepatic Function Associated with Nevirapine Therapy"],"prefix":"10.1177","volume":"11","author":[{"given":"S","family":"Clarke","sequence":"first","affiliation":[{"name":"Departments of Genito-Urinary Medicine, St James's Hospital, James's Street, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Harrington","sequence":"additional","affiliation":[{"name":"Departments of Genito-Urinary Medicine, St James's Hospital, James's Street, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Condon","sequence":"additional","affiliation":[{"name":"Departments of Pathology, St James's Hospital, James's Street, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Departments of Hepatology, St James's Hospital, James's Street, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O P","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Haematology, St James's Hospital, James's Street, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Mulcahy","sequence":"additional","affiliation":[{"name":"Departments of Genito-Urinary Medicine, St James's Hospital, James's Street, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"bibr1-095646240001100511","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.12.930"},{"key":"bibr2-095646240001100511","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.3.537"},{"key":"bibr3-095646240001100511","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199606000-00009"},{"key":"bibr4-095646240001100511","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-12-199606150-00001"},{"key":"bibr5-095646240001100511","unstructured":"Skowron G, Leoung G, Dusek A, Stavudine, nelfinavir, and nevirapine: preliminary safety, activity and pharmacokinetic (PK) interactions (Abstract 350). 6th Conference on Retroviruses and Opportunistic Infections, Chicago, January 1999."}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095646240001100511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095646240001100511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:31:14Z","timestamp":1777674674000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/095646240001100511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1177\/095646240001100511"],"URL":"https:\/\/doi.org\/10.1177\/095646240001100511","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}