{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:04:10Z","timestamp":1791194650919,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>The aim of the paper is to analyse the prevalence of liver involvement and related factors in HIV-infected patients with early syphilis (&lt;2 years). Liver involvement was defined as an elevation above normal ranges of alanine transaminase, aspartate aminotransferase, gamma-glutamyltransferase and\/or alkaline phosphatase during early syphilis, or doubling of previous levels in patients with liver enzyme elevation before syphilis. We undertook a multicentre study and of the 147 cases, 86.4% were men who had sex with men, and the diagnoses of syphilis and HIV infection were coincident in 48 (32.7%). Liver involvement was detected in 45 (30.6%) and the only related factor was a rapid plasma reagin (RPR) titre \u22651\/64 (odds ratio 3.76; 95% confidence interval 1.3\u201310.5; P = 0.012). In conclusion, liver involvement occurs in around one-third of HIV-infected patients with early syphilis and is associated with high RPR levels. Syphilis should be included in the differential diagnosis of liver enzyme elevation in HIV-infected patients.<\/jats:p>","DOI":"10.1177\/0956462412472316","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T18:04:43Z","timestamp":1369937083000},"page":"31-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Liver involvement in HIV-infected patients with early syphilis"],"prefix":"10.1177","volume":"24","author":[{"given":"R","family":"Palacios","sequence":"first","affiliation":[{"name":"UGC de Enfermedades Infecciosas, Hospital Virgen de la Victoria"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Navarro","sequence":"additional","affiliation":[{"name":"UGC de Enfermedades Infecciosas, Hospital Virgen de la Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Narankiewicz","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Hospital Carlos Haya, M\u00e1laga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Marcos","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Costa del Sol, Marbella, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Jim\u00e9nez-O\u00f1ate","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA)"},{"name":"Servicio de Enfermedades Infecciosas, Hospital Carlos Haya, M\u00e1laga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"de la Torre","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Costa del Sol, Marbella, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Santos","sequence":"additional","affiliation":[{"name":"UGC de Enfermedades Infecciosas, Hospital Virgen de la Victoria"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,6]]},"reference":[{"key":"IJSA-12-113C1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70296-X"},{"key":"IJSA-12-113C2","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(03)00023-0"},{"key":"IJSA-12-113C3","first-page":"729","volume":"7","author":"Wnuk AM","year":"2001","journal-title":"Med Sci Monit"},{"key":"IJSA-12-113C4","doi-asserted-by":"publisher","DOI":"10.1086\/425501"},{"key":"IJSA-12-113C5","first-page":"226","volume":"3","author":"De Miguel A","year":"2002","journal-title":"Mediafam"},{"key":"IJSA-12-113C6","doi-asserted-by":"publisher","DOI":"10.1086\/428848"},{"key":"IJSA-12-113C7","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082009001100011"},{"key":"IJSA-12-113C8","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008324"},{"key":"IJSA-12-113C9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.2.629"},{"key":"IJSA-12-113C10","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2005.19.545"},{"key":"IJSA-12-113C11","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01240-11"},{"key":"IJSA-12-113C12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92129-7"},{"key":"IJSA-12-113C13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197106242842507"},{"key":"IJSA-12-113C14","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1979.03630400079028"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462412472316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462412472316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462412472316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:31:38Z","timestamp":1777674698000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462412472316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1177\/0956462412472316"],"URL":"https:\/\/doi.org\/10.1177\/0956462412472316","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}