{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:36:40Z","timestamp":1777927000297,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Summary<\/jats:p>\n                  <jats:p>Data on baseline hepatic function of HIV and hepatitis B virus (HBV) co-infected patients are limited in sub-Saharan Africa. We assessed liver function test (LFT) abnormalities in Nigerian patients with HIV\/HBV co-infection to highlight the impact of HIV on HBV-related liver disease in sub-Saharan Africa. A cross-sectional study involving 100 HIV\/HBV co-infected patients and 100 age- and sex-matched HBV mono-infected controls. Blood testing for HIV antibodies, CD4+ cell count, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), LFTs, platelet count, fasting blood glucose and lipid profile were carried out. Non-invasive hepatic fibrosis scores (aspartate aminotransferase-platelet ratio index [APRI] and FIB-4) were also calculated. Co-infected patients had deranged liver enzymes more than the controls (77% versus 64%, P = 0.04). The predominant patterns of enzyme derangement in co-infected patients were either predominantly \u2191ALP (30% versus 4%, P &lt; 0.0001) or mixed (30% versus 15%, P = 0.01) but predominantly \u2191AST\/ALT in the controls (25% versus 9%, P = 0.003). Co-infected patients had higher fibrosis scores for both APRI ( P = 0.002) and FIB-4 ( P = 0.0001). On further analysis, LFT abnormalities and fibrosis scores were only significantly higher in co-infected patients in the immune clearance and HBeAg-negative chronic hepatitis phases. LFT abnormalities are common in Nigerians with HBV infection and co-infection with HIV negatively impacts on hepatic function.<\/jats:p>","DOI":"10.1177\/0956462412473889","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T23:41:01Z","timestamp":1372117261000},"page":"461-467","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Liver function test abnormalities in Nigerian patients with human immunodeficiency virus and hepatitis B virus co-infection"],"prefix":"10.1177","volume":"24","author":[{"given":"M O","family":"Iroezindu","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Enugu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O O","family":"Agbaji","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"AIDS Prevention Initiative Nigeria (APIN) Centre, Jos University Teaching Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Daniyam","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"AIDS Prevention Initiative Nigeria (APIN) Centre, Jos University Teaching Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G C","family":"Isiguzo","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Isichei","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, University of Jos, Jos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M O","family":"Akanbi","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"AIDS Prevention Initiative Nigeria (APIN) Centre, Jos University Teaching Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"bibr1-0956462412473889","first-page":"1","volume":"34","author":"Ojo OS","year":"1998","journal-title":"Niger Med J"},{"key":"bibr2-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.29401"},{"key":"bibr3-0956462412473889","volume-title":"AIDS Epidemic Update","author":"Joint United Nations Programme on HIV\/AIDS (UNAIDS)","year":"2010"},{"key":"bibr4-0956462412473889","first-page":"25","volume":"9","author":"Modi AA","year":"2007","journal-title":"AIDS Rev"},{"key":"bibr5-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1086\/381499"},{"key":"bibr6-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11913-1"},{"key":"bibr7-0956462412473889","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/135965350901400207","volume":"14","author":"Iser DM","year":"2009","journal-title":"Antiretroviral Ther"},{"key":"bibr8-0956462412473889","unstructured":"Price J, Seaberg EC, Badri S, Witt MD, D'Acunto K, Thio C.\n                      HAART Mitigates Liver Disease Progression in HIV\/Viral Hepatitis Co-infected Men\n                      . Proceedings of the International Conference on Viral Hepatitis. 11\u201313 April 2011. Baltimore, USA. Abstract 70670"},{"key":"bibr9-0956462412473889","unstructured":"StabinskiLKirkGDReynoldsSJ\n                      High Risk of Liver Fibrosis and Cirrhosis among HIV\/HBV Co-infected Persons in Rakai, Uganda\n                      . Proceedings of the International Conference on Viral Hepatitis. 11\u201313 April 2011, Baltimore, USA. Abstract 71277"},{"key":"bibr10-0956462412473889","first-page":"243","volume":"18","author":"Grant BF","year":"1992","journal-title":"Alcohol Health Res World"},{"key":"bibr11-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"bibr12-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"bibr13-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065904"},{"key":"bibr14-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-828674"},{"key":"bibr15-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199705000-00007"},{"key":"bibr16-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290447"},{"key":"bibr17-0956462412473889","first-page":"13","volume":"77","author":"Lodenyo H","year":"2000","journal-title":"East Afr Med J"},{"key":"bibr18-0956462412473889","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-8-678"},{"key":"bibr19-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008687"},{"key":"bibr20-0956462412473889","first-page":"8","volume":"8","author":"Ocama P","year":"2008","journal-title":"Afr Health Sci"},{"key":"bibr21-0956462412473889","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809090203"},{"key":"bibr22-0956462412473889","first-page":"239","volume":"67","author":"Mercey DE","year":"1991","journal-title":"Genitourin Med"},{"key":"bibr23-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.4.577"},{"key":"bibr24-0956462412473889","doi-asserted-by":"crossref","first-page":"626","DOI":"10.4314\/eamj.v81i10.9238","volume":"81","author":"Otedo AE","year":"2004","journal-title":"East Afr Med J"},{"key":"bibr25-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq199"},{"key":"bibr26-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1053\/bega.1999.0075"},{"key":"bibr27-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(89)90084-6"},{"key":"bibr28-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn531"},{"key":"bibr29-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq320"},{"key":"bibr30-0956462412473889","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2011.0191"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462412473889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462412473889","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462412473889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:32:01Z","timestamp":1777674721000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462412473889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1177\/0956462412473889"],"URL":"https:\/\/doi.org\/10.1177\/0956462412473889","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}