{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:23:13Z","timestamp":1789924993556,"version":"4.0.1"},"reference-count":8,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>We report here the first two cases of hepatobiliary pathology in HIV-positive men following recreational use of ketamine: &gt;1\u2009g\/day over a 12-month period while on ritonavir-based antiretroviral therapy. Presentation in each case was acute with nausea, vomiting and epigastric pain. Alanine aminotransferase was raised at 3.2\u00d7 and 10.1\u2009\u00d7\u2009upper limit of normal and alkaline phosphatase was raised at 1.7\u00d7 and 2.5\u2009\u00d7\u2009ULN for cases 1 and 2, respectively. Magnetic resonance cholangiopancreatography showed dilatation of the common bile duct; case 1, 18\u2009mm and case 2, 14\u2009mm with no ductal obstruction on endoscopic retrograde cholangiopancreatography. The symptoms resolved, common bile duct dilatation and liver function improved on discontinuation of ketamine use. Time to development of symptoms is shorter than reported in HIV-negative cases (12 months vs. 4 years) which may be explained by an interaction between ketamine and ritonavir.<\/jats:p>","DOI":"10.1177\/0956462413479894","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T22:11:19Z","timestamp":1374012679000},"page":"667-669","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Dilated common bile duct and deranged liver function tests associated with ketamine use in two HIV-positive MSM"],"prefix":"10.1177","volume":"24","author":[{"given":"Judith","family":"Zhou","sequence":"first","affiliation":[{"name":"The Lawson Unit, Brighton and Sussex University Hospital NHS Trust, Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon G","family":"Shaw","sequence":"additional","affiliation":[{"name":"The Lawson Unit, Brighton and Sussex University Hospital NHS Trust, Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Gilleece","sequence":"additional","affiliation":[{"name":"The Lawson Unit, Brighton and Sussex University Hospital NHS Trust, Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"bibr1-0956462413479894","doi-asserted-by":"publisher","DOI":"10.1159\/000095816"},{"key":"bibr2-0956462413479894","first-page":"44","volume":"225","author":"Dick D","year":"2010","journal-title":"MixMag2010"},{"key":"bibr3-0956462413479894","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02502.x"},{"key":"bibr4-0956462413479894","first-page":"310","volume":"5","author":"Selby NM","year":"2008","journal-title":"Nephrol Dial Transplant (Plus)"},{"key":"bibr5-0956462413479894","unstructured":"Ng SH, Lee HK, Chan YC, Lau FL. Dilated common bile duct in ketamine abusers.\n                      Hong Kong Med J\n                      2009; 15:157."},{"key":"bibr6-0956462413479894","first-page":"e52","volume":"52","author":"Lo RSC","year":"2011","journal-title":"Singapore Med J"},{"key":"bibr7-0956462413479894","first-page":"53","volume":"15","author":"Wong SW","year":"2009","journal-title":"Hong Kong Med J"},{"key":"bibr8-0956462413479894","first-page":"887","volume":"29","author":"Yanagihara Y","year":"2001","journal-title":"Drug Metab Dispos"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462413479894","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462413479894","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462413479894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:32:10Z","timestamp":1777674730000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462413479894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,16]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1177\/0956462413479894"],"URL":"https:\/\/doi.org\/10.1177\/0956462413479894","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,16]]}}}