{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:28:02Z","timestamp":1782512882124,"version":"3.54.5"},"reference-count":20,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>For the treatment of early infectious syphilis, enhanced therapy with three dosages of benzathine penicillin G has been under consideration, particularly in the human immunodeficiency virus type 1 infected population (HIV-1). The serological outcome of 249 patients with primary and secondary syphilis treated with standard or enhanced therapy was analyzed retrospectively; 98% (139\/142) achieved serological cure with a single dosage and 92% with enhanced therapy ( P\u2009=\u20090.033). In HIV-1 infected individuals, cure rates were 88% after a single dosage compared to 97% after three dosages ( P\u2009=\u20090.18). A fourfold decrease of Venereal Disease Research Laboratory (VDRL) titres was achieved within a median of 102 days after treatment initiation (SD\u2009=\u20092; 95% CI\u2009=\u200998\u2013106). Patients aged over 40 years were 5.5 times (OR\u2009=\u20095.52; 95% CI\u2009=\u20091.43\u201321.32; P\u2009=\u20090.013) and patients with low baseline VDRL titres (\u22641\u2009:\u200932) were 4 times (OR\u2009=\u20094.25; 95% CI\u2009=\u20091.21\u201314.87; P\u2009=\u20090.024) more likely to experience serological failure.<\/jats:p>","DOI":"10.1177\/0956462413480721","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T21:14:17Z","timestamp":1377724457000},"page":"703-711","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Enhanced therapy for primary and secondary syphilis: a longitudinal retrospective analysis of cure rates and associated factors"],"prefix":"10.1177","volume":"24","author":[{"given":"Julia","family":"Tittes","sequence":"first","affiliation":[{"name":"Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian C","family":"Aichelburg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Antoniewicz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Geusau","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"bibr1-0956462413480721","first-page":"1","volume":"59","author":"Workowski KA","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"bibr2-0956462413480721","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008510"},{"key":"bibr3-0956462413480721","doi-asserted-by":"publisher","DOI":"10.1086\/652239"},{"key":"bibr4-0956462413480721","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044284"},{"key":"bibr5-0956462413480721","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008104"},{"key":"bibr6-0956462413480721","unstructured":"World Medical Association Declaration of Helsinki. 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