{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:36:54Z","timestamp":1777927014082,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>There is currently no \u2018gold standard\u2019 for diagnosis of latent tuberculosis infection (LTBI), and both the tuberculin skin test and interferon-gamma release assays (IGRAs) are used for diagnosis; the latter have a higher sensitivity than tuberculin skin tests for diagnosis of LTBI in HIV-infected individuals with lower CD4 counts. No evidence base exists for selection of IGRA methodology to identify LTBI among human immunodeficiency virus-infected patients in the UK. We prospectively evaluated two commercially available IGRA methods (QuantiFERON-TB Gold In Tube [QFG] and T-SPOT.TB) for testing LTBI among HIV-infected patients potentially nosocomially exposed to an HIV-infected patient with \u2018smear-positive\u2019 pulmonary tuberculosis. Among the exposed patients median CD4 count was 550 cells\/\u00b5L; 105 (90%) of 117 were receiving antiretroviral therapy, of who 104 (99%) had an undetectable plasma HIV load. IGRAs were positive in 12 patients (10.3%); QFG positive in 11 (9.4%) and T-SPOT.TB positive in six (5.1%); both IGRAs were positive in five patients (4.3%). There was one indeterminate QFG and one borderline T-SPOT.TB result. Concordance between the two IGRAs was moderate ( \u03ba\u2009=\u20090.56, 95% confidence interval\u2009=\u20090.27\u20130.85). IGRAs were positive in only 4 (29%) of 14 patients with previous culture-proven tuberculosis. No patient developed tuberculosis during 20 months of follow-up.<\/jats:p>","DOI":"10.1177\/0956462413486459","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T21:45:00Z","timestamp":1373924700000},"page":"775-779","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of two interferon-gamma release assays (QuantiFERON-TB Gold In-Tube and T-SPOT.TB) in testing for latent tuberculosis infection among HIV-infected adults"],"prefix":"10.1177","volume":"24","author":[{"given":"B","family":"Sultan","sequence":"first","affiliation":[{"name":"Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, Institute of Epidemiology and Healthcare, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Benn","sequence":"additional","affiliation":[{"name":"Mortimer Market Centre, Camden Provider Services, Central and North West London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Mahungu","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Young","sequence":"additional","affiliation":[{"name":"Mortimer Market Centre, Camden Provider Services, Central and North West London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Mercey","sequence":"additional","affiliation":[{"name":"Mortimer Market Centre, Camden Provider Services, Central and North West London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Morris-Jones","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RF","family":"Miller","sequence":"additional","affiliation":[{"name":"Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, Institute of Epidemiology and Healthcare, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,7,15]]},"reference":[{"key":"bibr1-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12002"},{"key":"bibr2-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.9.1009"},{"key":"bibr3-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa031667"},{"key":"bibr4-0956462413486459","author":"Redelman-Sidi G","journal-title":"Am J Respir Crit Care Med."},{"issue":"5","key":"bibr5-0956462413486459","first-page":"1","volume":"59","author":"CDC","year":"2010","journal-title":"MMWR Morbid Mortal Wkly Rep"},{"key":"bibr6-0956462413486459","unstructured":"National Institute for Health and Clinical Excellence.\n                      Clinical diagnosis and management of tuberculosis, and measures for its prevention and control\n                      . CG117. London: National Institute for Health and Clinical Excellence, 2011. http:\/\/publications.nice.org.uk\/tuberculosis-cg117 (accessed 23 February 2013)."},{"key":"bibr7-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31820b07ab"},{"key":"bibr8-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114810"},{"key":"bibr9-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-15"},{"key":"bibr10-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-169"},{"key":"bibr11-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2575"},{"key":"bibr12-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268809002131"},{"key":"bibr13-0956462413486459","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"bibr14-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00753.x"},{"key":"bibr15-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03477.x"},{"key":"bibr16-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000191923.08938.5b"},{"key":"bibr17-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-107"},{"key":"bibr18-0956462413486459","unstructured":"Garrett D, Katz D and Chideya S. Prospective comparison of the tuberculin skin test and interferon-gamma release assays in diagnosing infection with\n                      Mycobacterium tuberculosis\n                      and in predicting progression to tuberculosis. http:\/\/www.clinicaltrials.gov\/ct2\/results?term=NCT01622140 (accessed 23 February 2013)."},{"key":"bibr19-0956462413486459","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2011.00954.x"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462413486459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462413486459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462413486459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:32:22Z","timestamp":1777674742000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462413486459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,15]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1177\/0956462413486459"],"URL":"https:\/\/doi.org\/10.1177\/0956462413486459","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,15]]}}}