{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:36:57Z","timestamp":1777927017580,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>To compare the rates of cure of septic abortion and pelvic inflammatory disease using a daily dose of clindamycin with gentamicin versus divided doses, we conducted a retrospective cohort study, where the electronic records of 661 patients who used clindamycin 1\u2009\u00d7\u2009, 3\u2009\u00d7\u2009or 4\u2009\u00d7\/day (groups 1, 3 and 4, respectively) between September 2002 and August 2010 were analysed. Major outcomes included rates of cure and failure according to the clinical records. Secondary endpoints were percentage of adverse effects related to medication regimen and the prevalence of positive VDRL and HIV. Similar conditions were observed in all groups \u2212 septic abortion: 167\/116\/123; pelvic inflammatory disease: 73\/95\/87 (groups 1, 3 and 4, respectively). No significant difference was found among groups for age or for rate of cure. Rates of cure (cure\/total [rate (95%CI)]) in groups 1, 3 and 4 were 236\/240 [0.983 (0.957\u22120.993)], 205\/211 [0.971 (0.939\u22120.986)], 203\/210 [0.966 (0.932\u22120.983)], respectively. Days of use of clindamycin was significantly reduced in group 1, compared to groups 3 and 4 (2.6\u2009\u00b1\u20091.3\u2009vs. 3.5\u2009\u00b1\u20092.5\u2009vs. 3.3\u2009\u00b1\u20091.9\u2212mean\u2009\u00b1\u2009SD; p\u2009&lt;\u20090.0001\u2009\u2013 ANOVA), but this may be due to differences in how length of therapy was measured and not the effect on clinical cure.<\/jats:p>","DOI":"10.1177\/0956462413487516","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T23:12:27Z","timestamp":1374275547000},"page":"893-898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Daily dose of clindamycin versus standard divided doses in obstetrical and gynecological infections: a retrospective cohort study"],"prefix":"10.1177","volume":"24","author":[{"given":"Cl\u00e1udia S","family":"Giugno","sequence":"first","affiliation":[{"name":"Departamento e Servi\u00e7o de Ginecologia e Obstetr\u00edcia, Universidade Federal do Rio Grande do Sul \u2013 Hospital de Cl\u00ednicas de Porto Alegre \u2013 Rua Ramiro Barcelos, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice L","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento e Servi\u00e7o de Ginecologia e Obstetr\u00edcia, Universidade Federal do Rio Grande do Sul \u2013 Hospital de Cl\u00ednicas de Porto Alegre \u2013 Rua Ramiro Barcelos, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele G","family":"Fuhrich","sequence":"additional","affiliation":[{"name":"Departamento e Servi\u00e7o de Ginecologia e Obstetr\u00edcia, Universidade Federal do Rio Grande do Sul \u2013 Hospital de Cl\u00ednicas de Porto Alegre \u2013 Rua Ramiro Barcelos, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola S","family":"Rabaioli","sequence":"additional","affiliation":[{"name":"Departamento e Servi\u00e7o de Ginecologia e Obstetr\u00edcia, Universidade Federal do Rio Grande do Sul \u2013 Hospital de Cl\u00ednicas de Porto Alegre \u2013 Rua Ramiro Barcelos, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia G","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departamento e Servi\u00e7o de Ginecologia e Obstetr\u00edcia, Universidade Federal do Rio Grande do Sul \u2013 Hospital de Cl\u00ednicas de Porto Alegre \u2013 Rua Ramiro Barcelos, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole C","family":"Sartor","sequence":"additional","affiliation":[{"name":"Departamento e Servi\u00e7o de Ginecologia e Obstetr\u00edcia, Universidade Federal do Rio Grande do Sul \u2013 Hospital de Cl\u00ednicas de Porto Alegre \u2013 Rua Ramiro Barcelos, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo F","family":"Savaris","sequence":"additional","affiliation":[{"name":"Departamento e Servi\u00e7o de Ginecologia e Obstetr\u00edcia, Universidade Federal do Rio Grande do Sul \u2013 Hospital de Cl\u00ednicas de Porto Alegre \u2013 Rua Ramiro Barcelos, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,7,19]]},"reference":[{"key":"bibr1-0956462413487516","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldg002"},{"key":"bibr2-0956462413487516","volume-title":"Williams gynecology","author":"Schorge JO","year":"2011","edition":"1"},{"key":"bibr3-0956462413487516","first-page":"1","volume":"59","author":"Workowski KA","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"bibr4-0956462413487516","volume-title":"Protein synthesis inhibitors and miscellaneous antibacterial agents. 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