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Of 5882 HIV-positive women from 15 studies, incidence ranged from 4.9 to 21.1 cases per 100 woman-years for any cervical lesion and 0.4 to 8.8 cases per 100 woman-years for high-grade cervical lesions. HIV-positive women showed a median three-fold higher incidence of cervical lesions compared to HIV-negative women. Of 1099 HIV-positive women from 11 studies, progression from low- to high-grade lesions ranged from 1.2 to 26.2 cases per 100 woman-years. Both incidence and progression rates increased with lower CD4 counts. The effect of antiretroviral therapy on the natural history of cervical neoplasia remains unclear. HIV-positive women have higher incidence and progression of cervical neoplasia. Cervical cancer screening should be integrated into HIV treatment programmes.<\/jats:p>","DOI":"10.1177\/0956462413491735","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T21:20:34Z","timestamp":1377811234000},"page":"163-177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":162,"title":["Incidence and progression of cervical lesions in women with HIV: a systematic global review"],"prefix":"10.1177","volume":"25","author":[{"given":"Sheri A","family":"Denslow","sequence":"first","affiliation":[{"name":"Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne F","family":"Rositch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Firnhaber","sequence":"additional","affiliation":[{"name":"Faculty of Health Science Department of Medicine, University of Witwatersrand, Johannesburg, South Africa"},{"name":"Right to Care, Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ting","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S","family":"Smith","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"bibr1-0956462413491735","unstructured":"UNAIDS, WHO. 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