{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:49:44Z","timestamp":1791838184081,"version":"4.3.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Increasing azithromycin treatment failure in sexually transmitted Mycoplasma genitalium infection, is linked to macrolide resistance and second-line treatment relies on the fluoroquinolone, moxifloxacin. We recently detected fluoroquinolone and macrolide resistance-associated mutations in 15% and 43%, respectively, of 143 initial M. genitalium PCR-positive specimens.<\/jats:p>\n                  <jats:p>For a subset of 33 Western Sydney Sexual Health Centre patients, clinical information and results of sequence analysis of M. genitalium macrolide and fluoroquinolone target genes \u2013 the 23S rRNA gene, and parC and gyrA, respectively \u2013 were used to examine whether mutations were associated with treatment failure. Macrolide resistance-associated mutations correlated with microbiological ( p\u2009=\u20090.013) and clinical ( p\u2009=\u20090.024) treatment failure, and fluoroquinolone resistance-associated mutations with microbiological moxifloxacin treatment failure ( p\u2009=\u20090.005). We describe the first reported cases of clinical and microbiological moxifloxacin treatment failure. Failure of first- and second-line antibiotic treatment of M. genitalium infection is occurring and likely to increase with current treatment strategies.<\/jats:p>","DOI":"10.1177\/0956462413502008","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T21:20:34Z","timestamp":1377811234000},"page":"822-828","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":140,"title":["Failure of moxifloxacin treatment in\n                    <i>Mycoplasma genitalium<\/i>\n                    infections due to macrolide and fluoroquinolone resistance"],"prefix":"10.1177","volume":"24","author":[{"given":"Deborah L","family":"Couldwell","sequence":"first","affiliation":[{"name":"Western Sydney Sexual Health Centre, Westmead Hospital, Parramatta, NSW, Australia"},{"name":"Sydney Emerging Infections and Biosecurity Institute, University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin A","family":"Tagg","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Macquarie University, North Ryde, NSW, Australia"},{"name":"Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neisha J","family":"Jeoffreys","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn L","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Sydney Emerging Infections and Biosecurity Institute, University of Sydney, Sydney, NSW, Australia"},{"name":"Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"bibr1-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-11"},{"key":"bibr2-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009499"},{"key":"bibr3-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1086\/499434"},{"key":"bibr4-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis1022"},{"key":"bibr5-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035593"},{"key":"bibr6-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2007.027375"},{"key":"bibr7-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008038"},{"key":"bibr8-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.05.011"},{"key":"bibr9-0956462413502008","doi-asserted-by":"crossref","unstructured":"Tagg KA, Jeoffreys NJ, Couldwell DL, et\u00a0al. Macrolide and fluoroquinolone resistance-associated mutations in\n                      Mycoplasma genitalium\n                      .\n                      J Clin Microbiol\n                      2013; 51: 2245\u20132249.","DOI":"10.1128\/JCM.00495-13"},{"key":"bibr10-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.683-692.2004"},{"key":"bibr11-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e31828bfccf"},{"key":"bibr12-0956462413502008","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-35"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462413502008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462413502008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462413502008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:32:53Z","timestamp":1777674773000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462413502008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1177\/0956462413502008"],"URL":"https:\/\/doi.org\/10.1177\/0956462413502008","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}