{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:24:06Z","timestamp":1790429046218,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Summary<\/jats:p>\n                  <jats:p>Akin to cervical cancer in sexually-active women, men who have sex with men (MSM) are predisposed to anal cancers, especially those with HIV co-infection. This cross-sectional study endeavored to assess the prevalence of anal dysplasia using Pap smears and p16 immunostaining amongst Indian MSM. A total of 31 consecutive HIV-positive and 34 HIV-negative MSM, from a cohort of sexually transmitted infection clinic attendees, underwent anal cytological evaluation with Pap smear and p16 staining. Chi square test and coefficient of correlation were used for comparison. Eighteen (27.7%) had abnormal anal cytology; increased in HIV-positive as compared to HIV-negative men (35% versus 20%, p\u2009=\u20090.180). Similarly, both low-grade (25.8% versus 17.6%) and high-grade lesions (8.3% versus 4.8%) were comparable in HIV-positive and HIV-negative group. Thirteen (20%) smears were p16-positive with a sensitivity and specificity for anal dysplasia of 72.3% and 100%, respectively. Anal cytology may be used to screen for anal dysplasia in MSM irrespective of HIV status. Furthermore, the addition of p16, with greater specificity for high-grade lesions, may improve diagnostic accuracy especially for high-grade lesions. A larger study to further corroborate these observations is warranted.<\/jats:p>","DOI":"10.1177\/0956462413518193","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T23:37:36Z","timestamp":1389915456000},"page":"726-733","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Anal cytology and p16 immunostaining for screening anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men: a cross-sectional study"],"prefix":"10.1177","volume":"25","author":[{"given":"Rahul","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Dermatology & STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Pandhi","sequence":"additional","affiliation":[{"name":"Department of Dermatology & STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit N","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Dermatology & STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vizodilhou A","family":"Yhome","sequence":"additional","affiliation":[{"name":"Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,16]]},"reference":[{"key":"bibr1-0956462413518193","unstructured":"Key facts on HIV epidemic and progress in regions and countries in 2010. Based on progress report 2011: Global HIV\/AIDS response, http:\/\/www.who.int\/hiv\/pub\/progress_report2011\/regional_facts\/en\/index1.html (2011, accessed 12 August 2012)."},{"key":"bibr2-0956462413518193","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000181012.62385.4a"},{"key":"bibr3-0956462413518193","unstructured":"WHO\/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human papillomavirus and related cancers in India. 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