{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:37:59Z","timestamp":1777927079437,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>We report a case of human herpes virus-8-associated multicentric Castleman\u2019s disease in an HIV-positive patient with hyponatraemia. A 65-year-old man was admitted with relapsing and remitting fever, scattered skin eruptions and hepatosplenomegaly following combination antiretroviral therapy for his HIV infection. Based on histopathological findings, he was diagnosed as having human herpes virus-8-associated multicentric Castleman\u2019s disease and was treated with four-weekly infusions of rituximab. Prior to receiving chemotherapy, we observed several suspected biomarkers of disease activity, positive correlations between plasma human herpes virus-8 viral load and the levels of plasma interleukin-6, C-reactive protein and soluble interleukin-2 receptor, and negative correlations between platelet count, albumin levels and especially serum sodium levels. We hypothesize that non-osmotic release of plasma antidiuretic hormone is a cause of hyponatraemia in human herpes virus-8-associated multicentric Castleman\u2019s disease and that relapsing and remitting hyponatraemia could be correlated with plasma human herpes virus-8 viral load.<\/jats:p>","DOI":"10.1177\/0956462414562050","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T23:43:19Z","timestamp":1418254999000},"page":"909-911","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Human herpes virus-8-associated multicentric Castleman\u2019s disease in an HIV-positive patient presenting with relapsing and remitting hyponatraemia"],"prefix":"10.1177","volume":"26","author":[{"given":"Hiroaki","family":"Sasaki","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Maeda","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hara","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morichika","family":"Osa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Imai","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Moriguchi","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Mikita","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Fujikura","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Kaida","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Kawana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"bibr1-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"bibr2-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.7.2130"},{"key":"bibr3-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200007)61:3<332::AID-JMV8>3.0.CO;2-3"},{"key":"bibr4-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.4.1360.1360"},{"key":"bibr5-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.6.2069.h8002069_2069_2073"},{"key":"bibr6-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1136\/sti.79.3.179"},{"key":"bibr7-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413477557"},{"key":"bibr8-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-290213"},{"key":"bibr9-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-335620"},{"key":"bibr10-0956462414562050","doi-asserted-by":"publisher","DOI":"10.1159\/000322238"}],"container-title":["International Journal of STD &amp; 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