{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:00Z","timestamp":1777927080415,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>This study examines the relationship between CD4 count and cervical cytological abnormality in HIV-positive women attending two district general hospital genitourinary medicine clinics in the East of England. It aims to determine whether the rate of cervical cytological abnormalities differs in HIV-positive women with CD4 count &gt;350\u2009cells\/\u00b5l and those with CD4 count \u2264350\u2009cells\/\u00b5l; and to compare the rates of abnormalities with that of the general population. We retrospectively reviewed data from a cross-sectional audit undertaken between December 2010 and December 2011 and analysed them using multivariable statistics. There was a significant association between recent CD4 count \u2264350\u2009cells\/\u00b5l and cervical cytological abnormality (p\u2009&lt;\u20090.001). A total of 6.3% of women with recent CD4 counts &gt;350\u2009cells\/\u00b5l had abnormal cervical smear results, compared with 6.6% of the general population in the screening period 2010\u201311 and 7.2% of the general population in the screening period 2009\u201310. In our study population of women with recent CD4 counts &gt;350\u2009cells\/\u00b5l, the proportions of mild, moderate and severe dysplasia were also similar to national figures. This raises important questions about the cost effectiveness of blanket annual screening for HIV-positive women.<\/jats:p>","DOI":"10.1177\/0956462414563624","type":"journal-article","created":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T20:27:10Z","timestamp":1418502430000},"page":"945-950","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cervical screening in HIV-positive women in the East of England: recent CD4 as the predictive risk factor"],"prefix":"10.1177","volume":"26","author":[{"given":"Olubanke","family":"Davies","sequence":"first","affiliation":[{"name":"Department of Genitourinary medicine, Watford General Hospital, Watford, Hertfordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasikala","family":"Rajamanoharan","sequence":"additional","affiliation":[{"name":"Department of Genitourinary medicine, Watford General Hospital, Watford, Hertfordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thambiah","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Department of Genitourinary medicine, Luton & Dunstable Hospital NHS Foundation Trust, Luton, Bedford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"bibr1-0956462414563624","doi-asserted-by":"publisher","DOI":"10.1086\/376996"},{"key":"bibr2-0956462414563624","doi-asserted-by":"publisher","DOI":"10.1086\/650467"},{"key":"bibr3-0956462414563624","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835536a3"},{"key":"bibr4-0956462414563624","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh192"},{"key":"bibr5-0956462414563624","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.15.2.17382"},{"key":"bibr6-0956462414563624","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2011.00971.x"},{"key":"bibr7-0956462414563624","unstructured":"NHS Cervical Screening Programme. Colposcopy and programme management. Guidelines for the NHS Cervical Screening Programme. 2nd ed. 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