{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:01Z","timestamp":1777927081298,"version":"3.51.4"},"reference-count":3,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>We report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.<\/jats:p>","DOI":"10.1177\/0956462414563630","type":"journal-article","created":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T20:27:10Z","timestamp":1418502430000},"page":"912-914","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution"],"prefix":"10.1177","volume":"26","author":[{"given":"Juri","family":"Katchanov","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Gastroenterology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Blechschmidt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vivantes Klinikum Neuk\u00f6lln, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordian","family":"Branding","sequence":"additional","affiliation":[{"name":"Department of Radiology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keikawus","family":"Arast\u00e9h","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Gastroenterology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Tintelnot","sequence":"additional","affiliation":[{"name":"Reference Laboratory for Cryptococcus neoformans, Robert Koch Institute, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Meintjes","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R","family":"Boulware","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Stocker","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Gastroenterology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"bibr1-0956462414563630","first-page":"S3","author":"Musubire AK","year":"2013","journal-title":"J AIDS Clin Res"},{"key":"bibr2-0956462414563630","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70170-5"},{"key":"bibr3-0956462414563630","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000384"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462414563630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462414563630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462414563630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:34:34Z","timestamp":1777674874000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462414563630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,12]]},"references-count":3,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1177\/0956462414563630"],"URL":"https:\/\/doi.org\/10.1177\/0956462414563630","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,12]]}}}