{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:05Z","timestamp":1777927085280,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Ureaplasma parvum, which has been recognised as a coloniser in the male urethra, is detected in some men with non-gonococcal urethritis. In this study, we quantified the 16\u2009S rRNA genes of U. parvum by a real-time polymerase chain reaction-based assay in first-voided urine from 15 symptomatic and 38 asymptomatic men who were positive only for U. parvum. We also determined the leukocyte counts by automated quantitative urine particle analysis in their first-voided urine. Positive correlations were observed between copies of the 16\u2009S rRNA genes of U. parvum\/ml and the leukocyte counts\/\u00b5l in first-voided urine ( p\u2009=\u20090.0019). The loads of \u226510\n                    <jats:sup>4<\/jats:sup>\n                    copies of the 16\u2009S rRNA gene\/ml, corresponding to \u22655\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    cells of U. parvum\/ml, were significantly associated with the presence of \u226512.5\u00a0leukocytes\/\u00b5l in first-voided urine that might document the presence of inflammatory responses in the urethra. However, a large portion of the subjects (83.0%) had bacterial loads of &lt;5\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    cells of U. parvum\/ml, and 79.5% of them showed &lt;12.5\u00a0leukocytes\/\u00b5l. The ambiguity of the pathogenic role of U. parvum in non-gonococcal urethritis could, in part, be due to its low bacterial loads, which might not give rise to inflammatory responses in the male urethra.\n                  <\/jats:p>","DOI":"10.1177\/0956462414565796","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T05:25:47Z","timestamp":1418966747000},"page":"1035-1039","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Bacterial loads of\n                    <i>Ureaplasma parvum<\/i>\n                    contribute to the development of inflammatory responses in the male urethra"],"prefix":"10.1177","volume":"26","author":[{"given":"Takashi","family":"Deguchi","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Research & Development\/Clinical Department, LSI Medience Corporation, Katori-Gun, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsuke","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensaku","family":"Seike","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Gifu University, Gifu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Ito","sequence":"additional","affiliation":[{"name":"iClinic, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"bibr1-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-001-0665-1"},{"key":"bibr2-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1097\/01.OLQ.0000114653.26951.71"},{"key":"bibr3-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2004.00887.x"},{"key":"bibr4-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2009.040394"},{"key":"bibr5-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009499"},{"key":"bibr6-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000243621.89212.40"},{"key":"bibr7-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413504556"},{"key":"bibr8-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.5.1850-1855.2003"},{"key":"bibr9-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1038\/35037619"},{"key":"bibr10-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2014.08.002"},{"key":"bibr11-0956462414565796","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000158932.78183.95"}],"container-title":["International Journal of STD &amp; 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