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HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two-newly diagnosed patients, during antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted infections. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch.<\/jats:p>","DOI":"10.1177\/0956462415571671","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T20:08:27Z","timestamp":1423339707000},"page":"66-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance"],"prefix":"10.1177","volume":"27","author":[{"given":"Fabiola","family":"Martin","sequence":"first","affiliation":[{"name":"Centre for Immunology and Infection, Department of Biology, University of York, York, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[{"name":"Genitourinary Department, Josephine Butler Centre King Street Health Centre, Wakefield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Thomson","sequence":"additional","affiliation":[{"name":"Centre for Virus Research, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Tarrant","sequence":"additional","affiliation":[{"name":"Genitourinary Department, York Teaching Hospital, York, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony","family":"Hale","sequence":"additional","affiliation":[{"name":"Department of Virology, Leeds Teaching Hospitals Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J","family":"Lacey","sequence":"additional","affiliation":[{"name":"Centre for Immunology and Infection, Department of Biology, University of York, York, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,2,7]]},"reference":[{"key":"bibr1-0956462415571671","unstructured":"BHIVA. 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