{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:33Z","timestamp":1777927113822,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Previous studies have reported that protease inhibitors (PIs) can contribute to glycaemic alterations. However, there are few trials examining the direct effect of a single PI. The objective of the study was to evaluate the modifications of glucose and lipid profiles after a switch from lopinavir\/ritonavir (LPV\/r) to atazanavir, used as ritonavir-boosted (ATV\/r) or un-boosted. We conducted a retrospective observational cohort study on the effect of ATV\/(r) on glycaemic metabolism (ATAGLU) in patients with undetectable levels of HIV-RNA who switched from LPV\/r. In total, 235 patients treated for 48 weeks with LPV\/r plus two nucleoside reverse transcriptase inhibitors (NRTIs) and with undetectable HIV-RNA were included: 134 continued LPV\/r after the initial 48 weeks and 101 switched to ATV(\/r) (18.3% to ATV; 24.7% to ATV\/r). A significant decrease in mean glucose level and insulin resistance was observed in patients who switched to ATV(\/r). The mean cholesterol triglyceride levels increased in the LPV\/r group and decreased among the patients who switched. A significant increase of CD4 T cells with undetectable levels of HIV-RNA was observed in all groups. The long-term results obtained in this real-life study suggest that patients who have achieved initial suppression on a regimen including LPV\/r\u2009+\u2009two NRTIs can switch to ATV\/(r)\u2009+\u2009two NRTIs with an improvement in lipid and glycaemic metabolism.<\/jats:p>","DOI":"10.1177\/0956462415590724","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T20:14:57Z","timestamp":1434053697000},"page":"638-643","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of switching from lopinavir\/ritonavir to boosted and un-boosted atazanavir on glucose metabolism: the ATAzanavir &amp; GLUcose metabolism (ATAGLU) study"],"prefix":"10.1177","volume":"27","author":[{"given":"Gabriella","family":"d\u2019Ettorre","sequence":"first","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Zaccarelli","sequence":"additional","affiliation":[{"name":"Clinical Department, National Institute for infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Ascoli-Bartoli","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"bibr1-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1086\/317491"},{"key":"bibr2-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31818651e6"},{"key":"bibr3-0956462415590724","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0633"},{"key":"bibr4-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31819c291b"},{"key":"bibr5-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.10.1179"},{"key":"bibr6-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200303010-00009"},{"key":"bibr7-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200408150-00003"},{"key":"bibr8-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200411050-00005"},{"key":"bibr9-0956462415590724","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.10.1643"},{"key":"bibr10-0956462415590724","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.12.3320"},{"key":"bibr11-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-014-0219-7"},{"key":"bibr12-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70271-8"},{"key":"bibr13-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0369-9"},{"key":"bibr14-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1310\/hct1305-233"},{"key":"bibr15-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0648"},{"key":"bibr16-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000266"},{"key":"bibr17-0956462415590724","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12121"},{"key":"bibr18-0956462415590724","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/infdis\/jir188","volume":"203","author":"McComsey 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