{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:46Z","timestamp":1777927126682,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Syphilis infection in pregnancy is known to cause a number of severe adverse pregnancy outcomes, including second-trimester miscarriage, stillbirth, very pre-term delivery and neonatal death, in addition to congenital syphilis. A retrospective review of women with positive syphilis serology and a pregnancy outcome between 2005 and 2012 in Leeds, UK, was performed. In all, 57 cases of positive syphilis serology in pregnancy were identified: 24 with untreated syphilis treated in the current pregnancy (Group 1); seven with reported but unconfirmed prior treatment who were retreated (Group 2); and 26 adequately treated prior to pregnancy (Group 3). The rate of severe adverse pregnancy outcomes in Group 1 at 21% was significantly higher than the 0% outcome of Group 3 ( p\u2009=\u20090.02). The severe adverse pregnancy outcomes were two second-trimester miscarriages, two pre-term births at 25 and 28 weeks and one stillbirth at 32 weeks. There were no cases of term congenital syphilis or term neonatal death, but we observed high rates of other adverse pregnancy outcomes despite treatment during pregnancy. Rapid referral for treatment is needed before 18 weeks in order to minimise adverse pregnancy outcomes.<\/jats:p>","DOI":"10.1177\/0956462415609862","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T20:10:11Z","timestamp":1443730211000},"page":"1108-1113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Adverse pregnancy outcomes following syphilis treatment in pregnancy in the UK"],"prefix":"10.1177","volume":"27","author":[{"given":"Harriet E","family":"Wallace","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E","family":"Isitt","sequence":"additional","affiliation":[{"name":"University of Leeds Medical School, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet M","family":"Broomhall","sequence":"additional","affiliation":[{"name":"University of Leeds Medical School, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison E","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-0956462415609862","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-S3-S9"},{"key":"bibr2-0956462415609862","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.103515"},{"key":"bibr3-0956462415609862","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<119::AID-PD39>3.0.CO;2-T"},{"key":"bibr4-0956462415609862","unstructured":"Public Health England. Recent epidemiology of infectious syphilis and congenital syphilis. Health Protection Report volume 7 (44). https:\/\/www.gov.uk\/government\/publications\/infectious-syphilis-and-congenital-syphilis-recent-epidemiology (2013, accessed 1 June 2015)."},{"key":"bibr5-0956462415609862","unstructured":"Public Health England. Syphilis Serology. UK Standards for Microbiology Investigations. V 44 Issue 2. https:\/\/www.gov.uk\/uk-standards-for-microbiology-investigations-smi-quality-and-consistency-in-clinical-laboratories (2015, accessed 1 June 2015)."},{"key":"bibr6-0956462415609862","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008279"},{"key":"bibr7-0956462415609862","unstructured":"Centers for Disease Control and Prevention. 2015 Sexually transmitted diseases treatment guidelines\n                      .\n                      http:\/\/www.cdc.gov\/std\/tg2015\/congenital.htm (2015, accessed 20 August 2015)."},{"key":"bibr8-0956462415609862","unstructured":"Centers for Disease Control and Prevention. Sexually Transmitted Diseases Data and Statistics. http:\/\/www.cdc.gov\/std\/stats\/congenitalsyphilisdef-rev-jan-2015.pdf (2015, accessed 1 June 2015)."},{"key":"bibr9-0956462415609862","unstructured":"Office for National Statistics, statistical bulletin. Births in England and Wales, 2012. http:\/\/www.ons.gov.uk\/ons\/dcp171778_317196.pdf (2013, accessed 1 June 2015)."},{"key":"bibr10-0956462415609862","unstructured":"Health and Social Care Information Centre. NHS Maternity Statistics \u2013 England, April 2011 to March 2012: NHS Maternity Statistics tables. http:\/\/www.hscic.gov.uk\/catalogue\/PUB09202\/nhs-mate-eng-2011-2012-tab-v1.xls (2012, accessed 1 June 2015)."},{"key":"bibr11-0956462415609862","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413512802"},{"key":"bibr12-0956462415609862","unstructured":"World Health Organisation. Elimination of mother to child transmission of HIV and syphilis. http:\/\/www.who.int\/reproductivehealth\/publications\/rtis\/9789241505888\/en\/ (2014, accessed 1 June 2015)."},{"key":"bibr13-0956462415609862","doi-asserted-by":"crossref","unstructured":"Kamb ML, Newman LM, Riley PL, et\u00a0al. A road map for the global elimination of congenital syphilis\n                      Obstet Gynaecol Int\n                      2010; 2010: 312798.","DOI":"10.1155\/2010\/312798"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462415609862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462415609862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462415609862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:35:34Z","timestamp":1777674934000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462415609862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1177\/0956462415609862"],"URL":"https:\/\/doi.org\/10.1177\/0956462415609862","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}