{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:49Z","timestamp":1777927129020,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>The 2008 UK syphilis guideline recommends infants born to women with any positive syphilis serology be followed up until both treponemal and nontreponemal tests are negative to exclude congenital syphilis, whereas Centers for Disease Control and Prevention guidelines recommend using only nontreponemal tests. Historically, we had low infant follow-up rates with no coherent pathways. We initiated a change in multidisciplinary team practice of infant testing for syphilis in 2011 and evaluated the results before and after by retrospective review of testing of infants born to women with positive syphilis serology between 2005 and 2012. A total of 28 infants\u2019 mothers were treated in pregnancy (termed \u2018high risk\u2019); 26 had adequate treatment prior to pregnancy (termed \u2018low risk\u2019). There was a significant increase in serological testing after 2011 compared with before (83% versus 48%; OR 5.07 [95% CI 1.22\u201322.77] p\u2009=\u20090.01) but mainly in low risk infants with no significant improvement in high risk infants who are the priority group. Using nontreponemal tests only in the infants would have reduced the tests required by at least 50%, allowing health resources to be concentrated on achieving adequate follow-up for those infants most at risk.<\/jats:p>","DOI":"10.1177\/0956462415612394","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T19:57:52Z","timestamp":1445025472000},"page":"1213-1217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Serological follow-up of infants born to mothers with positive syphilis serology \u2013 real-world experiences"],"prefix":"10.1177","volume":"27","author":[{"given":"Harriet E","family":"Wallace","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medicine, Leeds Teaching Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet M","family":"Broomhall","sequence":"additional","affiliation":[{"name":"University of Leeds Medical School, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E","family":"Isitt","sequence":"additional","affiliation":[{"name":"University of Leeds Medical School, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence S","family":"Miall","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Leeds Teaching Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, Leeds Teaching Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"bibr1-0956462415612394","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-S3-S9"},{"key":"bibr2-0956462415612394","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.103515"},{"key":"bibr3-0956462415612394","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<119::AID-PD39>3.0.CO;2-T"},{"key":"bibr4-0956462415612394","doi-asserted-by":"crossref","unstructured":"Peterman TA, Newman DR, Davis D, et\u00a0al. Do women with persistently negative nontreponemal test results transmit syphilis during pregnancy?\n                      Sex Transm Dis\n                      2013; 40: 311\u2013315","DOI":"10.1097\/OLQ.0b013e318285c5a7"},{"key":"bibr5-0956462415612394","unstructured":"Public Health England. Syphilis Serology. UK Standards for Microbiology Investigations. 2015; 44: Issue 2. Available at: https:\/\/www.gov.uk\/guidance\/uk-standards-for-microbiology-investigations-smi-quality-and-consistency-in-clinical-laboratories (accessed 1 June 2015)"},{"key":"bibr6-0956462415612394","unstructured":"Centers for Disease Control and Prevention. 2015 STD Treatment Guidelines: Congenital syphilis. Available at: www.cdc.gov\/std\/tg2015\/congenital.htm (accessed 18 August 2015)"},{"key":"bibr7-0956462415612394","first-page":"68","volume":"71","author":"Chang SN","year":"1995","journal-title":"Genitourinary Med"},{"key":"bibr8-0956462415612394","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008279"},{"key":"bibr9-0956462415612394","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.121541"},{"key":"bibr10-0956462415612394","doi-asserted-by":"crossref","unstructured":"Wallace HE, Isitt CE, Broomhall HM, et\u00a0al. Adverse pregnancy outcomes following syphilis treatment during pregnancy in the UK.\n                      Int J STD AIDS\n                      . Epub ahead of print 30 September 2015. DOI:10.1177\/0956462415609862","DOI":"10.1177\/0956462415609862"},{"key":"bibr11-0956462415612394","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.069377"},{"key":"bibr12-0956462415612394","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050684"},{"issue":"1","key":"bibr13-0956462415612394","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1258\/ijsa.2012.012092","volume":"24","author":"Garley J","year":"2013","journal-title":"Int J STD AIDS"},{"issue":"1","key":"bibr14-0956462415612394","first-page":"68","volume":"24","author":"Wallace HE","year":"2013","journal-title":"Int J STD AIDS"},{"key":"bibr15-0956462415612394","doi-asserted-by":"crossref","unstructured":"Kingston M, French P, Higgins S, et al. UK National Guidelines on the management of syphilis.\n                      Int J STD AIDS\n                      2015; 27: 421\u2013446","DOI":"10.1177\/0956462415624059"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462415612394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462415612394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462415612394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:35:39Z","timestamp":1777674939000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462415612394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,29]]},"references-count":15,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1177\/0956462415612394"],"URL":"https:\/\/doi.org\/10.1177\/0956462415612394","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,29]]}}}