{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:46:07Z","timestamp":1782513967803,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Recent data suggest that azithromycin may not be as effective as doxycycline in eradication of genital chlamydial infection. The aim of this study was to compare the eradication rate of pharyngeal Chlamydia trachomatis infection after treatment with azithromycin 1\u2009g stat with that of doxycycline 100\u2009mg twice a day for seven days. A prospective open-label observational study was conducted on patients with pharyngeal Chlamydia trachomatis diagnosed at Whittall Street Clinic, University Hospitals Birmingham, Birmingham, UK, between July 2012 and July 2013. We confirmed eradication of pharyngeal Chlamydia trachomatis with a negative test of cure. We treated all our patients with azithromycin 1\u2009g stat until February 2013. At that stage, we offered doxycycline to patients with pharyngeal Chlamydia trachomatis. A total of 398 patients (52 men, 346 women) were diagnosed with pharyngeal Chlamydia trachomatis during the study period. Of the 172 patients included in the final analysis, 78 were treated with azithromycin and 64 with doxycycline. Treatment failure was identified among 8\/78 (10%) patients treated with azithromycin and 1\/64 (2%) treated with doxycycline (absolute difference: 8 percentage points, 95% CI: 0\u201317%, p\u2009=\u20090.041). In our study, doxycycline 100\u2009mg twice a day for seven days was associated with less treatment failure of oropharyngeal chlamydia compared with azithromycin 1\u2009g stat. Future randomised studies should investigate whether patients with pharyngeal Chlamydia trachomatis should be followed up with a test of cure when treated with azithromycin, or be treated with doxycycline.<\/jats:p>","DOI":"10.1177\/0956462415614723","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T20:08:04Z","timestamp":1446062884000},"page":"1303-1308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of doxycycline with azithromycin in treatment of pharyngeal chlamydia infection"],"prefix":"10.1177","volume":"27","author":[{"given":"K","family":"Manavi","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham Whittall Street Clinic Whittall Street Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Hettiarachchi","sequence":"additional","affiliation":[{"name":"Surrey Sexual Health Service (Buryfields), Guildford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hodson","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham Whittall Street Clinic Whittall Street Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-0956462415614723","unstructured":"Public Health England. 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A cross-sectional study followed by a cohort study of untreated STI clinic patients in Amsterdam, The Netherlands.\n                      Sex Transm Infect\n                      2015; 91: 157\u2013164.","DOI":"10.1136\/sextrans-2014-051633"},{"key":"bibr3-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3182495e2f"},{"key":"bibr4-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e31821890e9"},{"key":"bibr5-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050929"},{"key":"bibr6-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.7.658"},{"key":"bibr7-0956462415614723","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-6-757"},{"key":"bibr8-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480030078041"},{"key":"bibr9-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62035-8"},{"key":"bibr10-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3182029008"},{"key":"bibr11-0956462415614723","doi-asserted-by":"publisher","DOI":"10.1086\/648427"},{"key":"bibr12-0956462415614723","unstructured":"British Association for Sexual Health and HIV (BASHH) (2010)\n                      Chlamydia trachomatis\n                      UK Testing Guidelines. Clinical Effectiveness Group. 2010 Update to Chlamydia testing, http:\/\/www.bashh.org\/documents\/61\/61.pdf (accessed 11 March 2015)."},{"key":"bibr13-0956462415614723","unstructured":"Centre for Disease Control and Prevention. 2010 STD treatment guidelines. 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