{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:38:55Z","timestamp":1777927135387,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Summary<\/jats:p>\n                  <jats:p>In Brazil, all patients who fulfill the criteria for AIDS have had free access to antiretroviral therapy since 1996. We performed this cross-sectional study to evaluate the causes of death among 643 HIV-infected patients over three non-consecutive years (2000, 2006, and 2010), using their epidemiological, clinical, and laboratory data. The causes of death were classified as AIDS-defining or non-AIDS-defining conditions. We observed a progressive increase in the prevalence of HIV infection over the study period, although there was also a decrease in the mortality rate for various groups, and especially among pediatric patients. An AIDS-defining condition was recorded as the cause of death for approximately 30% of the patients. There was also a high frequency (&gt;70%) of infectious and parasitic diseases, including opportunistic infections, and the most common diagnoses were septicemia, pneumonia, tuberculosis, and pneumocystosis. Acute respiratory failure was the underlying cause of death in 30% of these cases. Despite advances in HIV therapy, the mortality rate remains high in Brazil. As few Brazilian studies have investigated HIV\/AIDS-related mortality, it is important to evaluate and improve the mortality notification databases, in order to provide information regarding the effects of HIV and to guide the implementation of appropriate healthcare measures.<\/jats:p>","DOI":"10.1177\/0956462415624075","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T20:33:19Z","timestamp":1451939599000},"page":"54-62","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of public health strategies on reducing AIDS mortality in southern Brazil"],"prefix":"10.1177","volume":"28","author":[{"given":"Sonia M","family":"Raboni","sequence":"first","affiliation":[{"name":"Infectious Diseases Division, Universidade Federal do Paran\u00e1, Curitiba, Brazil"},{"name":"Virology Laboratory, Universidade Federal do Paran\u00e1, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clea E","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Universidade Federal do Paran\u00e1, Curitiba, Brazil"},{"name":"Secretaria Municipal de Sa\u00fade de Curitiba, Paran\u00e1, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio M","family":"Almeida","sequence":"additional","affiliation":[{"name":"Faculdades e Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo M","family":"Telles","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica de Curitiba, Paran\u00e1, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica de Curitiba, Paran\u00e1, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo A","family":"Schaitza","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Universidade Federal do Paran\u00e1, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"bibr1-0956462415624075","unstructured":"UNAIDS. Global AIDS response progress reporting 2014. http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/GARPR_2014_guidelines_en_0.pdf (accessed 26 February 2015)."},{"key":"bibr2-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"bibr3-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.1.51"},{"key":"bibr4-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005575"},{"key":"bibr5-0956462415624075","unstructured":"Brazilian Ministry of Health, Division of Health Surveillance, National Program on STD\/AIDS. 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Ades\u00e3o ao tratamento antiretroviral no Brasil: Colet\u00e2nea de estudos do projeto ATAR. 2010. http:\/\/www.aids.gov.br\/sites\/default\/files\/atar-web.pdf (accessed 16 February 2015)."},{"key":"bibr9-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822012000400006"},{"key":"bibr10-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31817efb54"},{"key":"bibr11-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1086\/652283"},{"key":"bibr12-0956462415624075","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.18.1.20016"},{"key":"bibr13-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1530-y"},{"key":"bibr14-0956462415624075","unstructured":"Municipal Health Department, Curitiba-PR. HIV\/AIDS Epidemiological Bulletin. 2014. http:\/\/multimidia.curitiba.pr.gov.br\/2014\/00156481.pdf (accessed 26 March 2015)."},{"key":"bibr15-0956462415624075","unstructured":"Brazilian Health Ministry. Recomenda\u00e7\u00f5es para terapia antirretroviral em adultos infectados pelo HIV. 2008. http:\/\/www.aids.gov.br\/sites\/default\/files\/consensoAdulto005c_2008montado.pdf (accessed 15 July 2015)."},{"key":"bibr16-0956462415624075","unstructured":"WHO. International Statistical Classification of Diseases and Related Health Problems 10th Revision Geneva: World Health Organization; 1992. http:\/\/apps.who.int\/classifications\/icd10\/browse\/2015\/en (accessed 23 March 2015)."},{"key":"bibr17-0956462415624075","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102000000600004"},{"key":"bibr18-0956462415624075","unstructured":"State Department of Health of S\u00e3o Paulo. STD\/AIDS Reference and Training Center. Dados para repensar a AIDS no estado de S\u00e3o Paulo. 2011. http:\/\/produtos.seade.gov.br\/produtos\/publicacoes\/pub_Repensar_Aids_2011.pdf (accessed 23 March 2015)."},{"key":"bibr19-0956462415624075","unstructured":"Brazilian Health Ministry. 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