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It does not recommend testing asymptomatic men for the presence of urethritis. All men with urethritis should be tested for Chlamydia trachomatis and Neisseria gonorrhoeae and ideally Mycoplasma genitalium using a nucleic acid amplification test (NAAT) as this is highly likely to improve clinical outcomes. If a NAAT is positive for gonorrhoea, a culture should be performed before treatment. In view of the increasing evidence that azithromycin 1\u2009g may result in the development of antimicrobial resistance in M. genitalium, azithromycin 1\u2009g is no longer recommended as first line therapy, which should be doxycycline 100\u2009mg bd for seven days. If azithromycin is to be prescribed an extended course of 500\u2009mg stat, then 250\u2009mg daily for four days is to be preferred over 1\u2009g stat. In men with persistent NGU, M. genitalium NAAT testing is recommended if not previously undertaken, as is Trichomonas vaginalis NAAT testing in populations where T. vaginalis is detectable in &gt;2% of symptomatic women.<\/jats:p>","DOI":"10.1177\/0956462416648585","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:09:44Z","timestamp":1462406984000},"page":"928-937","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":163,"title":["2016 European guideline on the management of non-gonococcal urethritis"],"prefix":"10.1177","volume":"27","author":[{"given":"Patrick J","family":"Horner","sequence":"first","affiliation":[{"name":"School of Social and Community Medicine, University of Bristol, UK"},{"name":"Bristol Sexual Health Centre, University Hospitals Bristol NHS Foundation Trust, 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