{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:22Z","timestamp":1777927162680,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,10,23]],"date-time":"2016-10-23T00:00:00Z","timestamp":1477180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>A retrospective audit of plasma human herpesvirus-8 (HHV-8) viral load testing was performed in three HIV treatment centres over 24 months. Reasons for testing (360 tests) were: symptoms of systemic inflammatory response syndrome (SIRS) (fever, lymphadenopathy and raised inflammatory markers); monitoring in known HHV-8 pathology other than Kaposi sarcoma (KS); investigation of known\/suspected KS, and other\/no reason. Of patients with multicentric Castleman disease (MCD), 14\/16 (88%) had detectable plasma HHV-8, as did 27\/45 (60%) with biopsy proven or clinically confirmed KS, and 6\/19 (32%) with lymphoma. Neither of the two patients with MCD and no detectable HHV-8 had SIRS symptoms at the time of the test. There was wide variation between centres in the indications prompting HHV-8 testing, with a more conservative approach resulting in a higher proportion of positive results. Measuring plasma HHV-8 in the absence of SIRS symptoms, established HHV-8 disease monitoring, or confirmed\/suspected KS is unlikely to yield detectable HHV-8 thus allowing potential cost savings.<\/jats:p>","DOI":"10.1177\/0956462416676031","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T21:59:11Z","timestamp":1477000751000},"page":"188-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of plasma human herpesvirus-8 viral load measurement: evaluation of practice in three UK HIV treatment centres"],"prefix":"10.1177","volume":"28","author":[{"given":"DB","family":"Nugent","sequence":"first","affiliation":[{"name":"Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Webster","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Mabayoje","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Chung","sequence":"additional","affiliation":[{"name":"Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"El Bouzidi","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Ainsworth","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RF","family":"Miller","sequence":"additional","affiliation":[{"name":"Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, UK"},{"name":"University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,23]]},"reference":[{"key":"bibr1-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.103"},{"key":"bibr2-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn697"},{"key":"bibr3-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2011.010464"},{"key":"bibr4-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12273"},{"key":"bibr5-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000287"},{"key":"bibr6-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.05.005"},{"key":"bibr7-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12136"},{"key":"bibr8-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-335620"},{"key":"bibr9-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e328319bca9"},{"key":"bibr10-0956462416676031","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e328349c233"},{"key":"bibr11-0956462416676031","first-page":"207","volume":"10","author":"Bower M","year":"2012","journal-title":"Clin Adv Haematol Oncol"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462416676031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462416676031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462416676031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:36:36Z","timestamp":1777674996000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462416676031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,23]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/0956462416676031"],"URL":"https:\/\/doi.org\/10.1177\/0956462416676031","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,23]]}}}