{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:21:37Z","timestamp":1790490097858,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1091226"],"award-info":[{"award-number":["1091226"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1091536"],"award-info":[{"award-number":["1091536"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1094518"],"award-info":[{"award-number":["1094518"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>The objective of this study was to determine the incidence and predictors of Fanconi Syndrome (FS) in a cohort of patients taking tenofovir disoproxil fumarate (TDF). Clinical records and laboratory investigations from patients receiving TDF between 2002 and 2016 were extracted. FS was defined as normoglycaemic glycosuria and proteinuria and at least one other marker of renal dysfunction. Regression analysis was performed with time to development of FS and the following covariates: ritonavir co-administration, age, gender, co-morbidities (hypertension, hyperlipidaemia, diabetes, viral hepatitis), CD4 cell count nadir and baseline eGFR. One thousand and forty-four patients received TDF without ritonavir and 398 patients with ritonavir. Thirteen cases of FS were identified with a mean duration of exposure of 55 months. The incidence of FS was 1.09\/1000PY (0.54\u20131.63) of TDF exposure (without ritonavir) and 5.50\/1000PY (3.66\u20137.33) of TDF-ritonavir co-administration (p=0.0057). The adjusted hazards ratio for ritonavir co-administration was 4.71 (1.37\u201316.14, p=0.014). Known risk factors for chronic kidney disease were not associated with development of FS. Ritonavir co-administration, but not other factors, is associated with a greater risk of FS. FS developed late. Known risk factors for chronic kidney disease and length of treatment are not useful for identifying patients most at risk of developing FS in patients taking TDF.<\/jats:p>","DOI":"10.1177\/0956462417722133","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:49:42Z","timestamp":1501634982000},"page":"227-236","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Incidence of renal Fanconi syndrome in patients taking antiretroviral therapy including tenofovir disoproxil fumarate"],"prefix":"10.1177","volume":"29","author":[{"given":"Nicholas A","family":"Medland","sequence":"first","affiliation":[{"name":"Monash University Central Clinical School, Carlton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric PF","family":"Chow","sequence":"additional","affiliation":[{"name":"Monash University Central Clinical School, Carlton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan G","family":"Walker","sequence":"additional","affiliation":[{"name":"Alfred Hospital, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Chen","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Carlton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim RH","family":"Read","sequence":"additional","affiliation":[{"name":"Alfred Health, Carlton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K","family":"Fairley","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Carlton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"bibr1-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200304110-00026"},{"key":"bibr2-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.36924"},{"key":"bibr3-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1086\/368314"},{"key":"bibr4-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct258"},{"key":"bibr5-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2627-x"},{"key":"bibr6-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.124"},{"key":"bibr7-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832c96e9"},{"key":"bibr8-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2007.0052"},{"key":"bibr9-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.028233"},{"key":"bibr10-0956462417722133","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00248"},{"key":"bibr11-0956462417722133","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/135965350701200211","volume":"12","author":"Cihlar T","year":"2007","journal-title":"Antivir Ther"},{"key":"bibr12-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1086\/655681"},{"key":"bibr13-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.01.010"},{"key":"bibr14-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092717"},{"key":"bibr15-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127726"},{"key":"bibr16-0956462417722133","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"bibr17-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-11-35"},{"key":"bibr18-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu617"},{"key":"bibr19-0956462417722133","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents.\n                      Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents\n                      . Department of Health and Human Services. p C-3. Available at: http:\/\/www.aidsinfo.nih.gov\/ContentFiles\/AdultandAdolescentGL.pdf (accessed 17 July 2017)."},{"key":"bibr20-0956462417722133","unstructured":"World Health Organisation.\n                      Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection\n                      , Second Edition. WHO Press: Geneva, Switzerland, 2016. Available at: http:\/\/www.who.int\/hiv\/pub\/arv\/arv-2016\/en\/ (accessed 17 July 2017)."},{"key":"bibr21-0956462417722133","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1016\/S2352-3018(16)00024-2","volume":"3","author":"Gallant JE","year":"2016","journal-title":"Lancet HIV"},{"key":"bibr22-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12401"},{"key":"bibr23-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000908"},{"key":"bibr24-0956462417722133","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283262a64"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462417722133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462417722133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462417722133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:37:25Z","timestamp":1777675045000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462417722133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1177\/0956462417722133"],"URL":"https:\/\/doi.org\/10.1177\/0956462417722133","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,1]]}}}