{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:54Z","timestamp":1777927194178,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["Grant Code: IP.2007.33011.003"],"award-info":[{"award-number":["Grant Code: IP.2007.33011.003"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>There are limited data on the prevalence of risky sexual behaviours in individuals failing first-line antiretroviral therapy (ART) and changes in sexual behaviour after switch to second-line ART. We undertook a sexual behaviour sub-study of Ugandan adults enrolled in the Europe\u2013Africa Research Network for the Evaluation of Second-line Therapy trial. A standardized questionnaire was used to collect sexual behaviour data and, in particular, risky sexual behaviours (defined as additional sexual partners to main sexual partner, inconsistent use of condoms, non-disclosure to sexual partners, and exchange of money for sex). Of the 79 participants enrolled in the sub-study, 62% were female, median age (IQR) was 37 (32\u201342) years, median CD4 cell count (IQR) was 79 (50\u2013153) cells\/\u00b5l, and median HIV viral load log was 4.9 copies\/ml (IQR: 4.5\u20135.3) at enrolment. The majority were in long-term stable relationships; 69.6% had a main sexual partner and 87.3% of these had been sexually active in the preceding six months. At enrolment, around 20% reported other sexual partners, but this was higher among men than women (36% versus 6.7 %, p\u2009&lt;\u20090.001). In 50% there was inconsistent condom use with their main sexual partner and a similar proportion with other sexual partners, both at baseline and follow-up. Forty-three per cent of participants had not disclosed their HIV status to their main sexual partner (73% with other sexual partners) at enrolment, which was similar in men and women. Overall, there was no significant change in these sexual behaviours over the 96 weeks following switch to second-line ART, but rate of non-disclosure of HIV status declined significantly (43.6% versus 19.6%, p\u2009&lt;0.05). Among persons failing first-line ART, risky sexual behaviours were prevalent, which has implications for potential onward transmission of drug-resistant virus. There is need to intensify sexual risk reduction counselling and promotion of partner testing and disclosure, especially at diagnosis of treatment failure and following switch to second- or third-line ART.<\/jats:p>","DOI":"10.1177\/0956462417724707","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T03:31:44Z","timestamp":1502940704000},"page":"287-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Significant rates of risky sexual behaviours among HIV-infected patients failing first-line ART: A sub-study of the Europe\u2013Africa Research Network for the Evaluation of Second-line Therapy trial"],"prefix":"10.1177","volume":"29","author":[{"given":"Jane N","family":"Wanyama","sequence":"first","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S","family":"Nabaggala","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Wandera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes N","family":"Kiragga","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Castelnuovo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan K","family":"Mambule","sequence":"additional","affiliation":[{"name":"Institute of Infection and Global Health, University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Nakajubi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D","family":"Kambugu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas I","family":"Paton","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhoda K","family":"Wanyenze","sequence":"additional","affiliation":[{"name":"School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Colebunders","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Antwerp, Belgium"},{"name":"Global Health Institute, University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa","family":"Easterbrook","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"bibr1-0956462417724707","unstructured":"Joint United Nations Programme on HIV\/AIDS(UNAIDS). 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Available at: http:\/\/www.who.int\/hiv\/pub\/drugresistance\/ewi-hivdr-2016\/en\/ (2016, accessed 22 October 2016)."},{"key":"bibr6-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32834b4ced"},{"key":"bibr7-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-007-9279-7"},{"key":"bibr8-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1080\/09540120701426540"},{"key":"bibr9-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2007.007097"},{"key":"bibr10-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200317003-00010"},{"key":"bibr11-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2005.19.760"},{"key":"bibr12-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000196566.40702.28"},{"key":"bibr13-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2010.525616"},{"key":"bibr14-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000366079.83568.a2"},{"key":"bibr15-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.035147"},{"key":"bibr16-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-011-9941-y"},{"key":"bibr17-0956462417724707","doi-asserted-by":"crossref","unstructured":"Apondi R, Bunnell R, Ekwaru JP, et al. Sexual behaviour and HIV transmission risk of Ugandan adults taking antiretroviral therapy. 3 years follow-up.\n                      AIDS\n                      2011; 25: 1317\u20131327.","DOI":"10.1097\/QAD.0b013e328347f775"},{"key":"bibr18-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833616c7"},{"key":"bibr19-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833e78d4"},{"key":"bibr20-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1071\/SH09109"},{"key":"bibr21-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2007.0247"},{"key":"bibr22-0956462417724707","unstructured":"Wanyama J, Kasibante D, Kayiira P, et\u00a0al. Sexual behavior of HIV+ persons before and after 1 year of ART at the Infectious Diseases Clinic, Kampala, Uganda. 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The factors influencing transactional sex among young men and women in 12 sub-Saharan African countries.\n                      Soc Biol\n                      2005; 52: 56\u201372.","DOI":"10.1080\/19485565.2002.9989099"},{"key":"bibr34-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1177\/1043659604270962"},{"key":"bibr35-0956462417724707","doi-asserted-by":"publisher","DOI":"10.2307\/25549731"},{"key":"bibr36-0956462417724707","volume-title":"Women out loud: How women living with HIV will help the world ends AIDS, in United Nations Joint Programme on HIV\/AIDS","author":"UN","year":"2012"},{"key":"bibr37-0956462417724707","doi-asserted-by":"crossref","first-page":"iii18","DOI":"10.1136\/sti.2006.020081","volume":"82","author":"Vandepitte J","year":"2006","journal-title":"Sex Transm Infect"},{"key":"bibr38-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(96)00293-5"},{"key":"bibr39-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318227af4d"},{"key":"bibr40-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000135989.14131.9d"},{"key":"bibr41-0956462417724707","unstructured":"Snow R, Mutumba M, Powers G, et\u00a0al. 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Available at: http:\/\/apps.who.int\/iris\/bitstream\/10665\/255883\/1\/9789241512848-eng.pdf?ua=1 (2017, accessed 3 August 2017)."},{"key":"bibr60-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2014.01.039"},{"key":"bibr61-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318291fff4"},{"key":"bibr62-0956462417724707","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318254c84a"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462417724707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462417724707","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462417724707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:37:29Z","timestamp":1777675049000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462417724707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1177\/0956462417724707"],"URL":"https:\/\/doi.org\/10.1177\/0956462417724707","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}