{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:36:44Z","timestamp":1793507804374,"version":"4.5.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>The worldwide re-emergence of secondary syphilis which happened in the last decade, has led to an increase in primary and secondary syphilis cases, along with the presentation of atypical forms. Nevertheless, reports of renal syphilis with mucosal and\/or cutaneous manifestations are nowadays increasing. Typically, secondary syphilis infection in adults causes nephrotic syndrome due to a membranous glomerulonephritis. Here, we report a case of a 30-year-old immunocompetent man presenting with skin rash, oral and perianal erosions and nephritic syndrome. Laboratory investigations revealed a form of membranoproliferative glomerulonephritis secondary to Treponema pallidum infection. Therapy with benzathine penicillin brought prompt and complete remission of the disease. Although well described for congenital syphilis, this histopathologic pattern of renal involvement is very rarely reported in adult patients. In case of detection of an otherwise unexplained nephritic syndrome in sexually active patients with mucosal and\/or anal lesions, an unrecognized syphilis infection should be suspected.<\/jats:p>","DOI":"10.1177\/0956462417733351","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T04:42:37Z","timestamp":1506487357000},"page":"410-413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions"],"prefix":"10.1177","volume":"29","author":[{"given":"Linda","family":"Tognetti","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medical, Surgical and Neuro-Sciences, University Hospital of Siena, Siena, Italy"},{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Division of Human Pathology, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Garosi","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplant Unit, University Hospital of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medical, Surgical and Neuro-Sciences, University Hospital of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"bibr1-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.10.020"},{"key":"bibr2-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2015.03.003"},{"key":"bibr3-0956462417733351","first-page":"2013","volume":"8","author":"Handoko ML","year":"2013","journal-title":"BMJ Case Rep"},{"key":"bibr4-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1016\/S0755-4982(05)84007-2"},{"key":"bibr5-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12518"},{"key":"bibr6-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-013-0018-z"},{"key":"bibr7-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.5.375"},{"key":"bibr8-0956462417733351","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1681\/ASN.V371351","volume":"3","author":"Hunte W","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"bibr9-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011030304"},{"key":"bibr10-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"bibr11-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12681"},{"key":"bibr12-0956462417733351","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.01.029"},{"key":"bibr13-0956462417733351","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5070\/D34MT2626G","volume":"14","author":"Carlesimo M","year":"2008","journal-title":"Dermatol Online J"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462417733351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462417733351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462417733351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:37:38Z","timestamp":1777675058000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462417733351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1177\/0956462417733351"],"URL":"https:\/\/doi.org\/10.1177\/0956462417733351","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}