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Neurological evaluation revealed a striking burden of cerebrovascular disease for her age, including the rare stroke syndrome of basilar artery occlusion. Human immunodeficiency virus (HIV) infection was identified during clinical assessment. This was judged to be perinatally acquired, as there was no history of sexual debut or blood transfusion; her mother was taking antiretroviral therapy and she had facial planar warts and underlying bronchiectasis. Therefore, it has been concluded that presentation of stroke should prompt HIV testing in young people and perinatally-acquired infection can present in adulthood.<\/jats:p>","DOI":"10.1177\/0956462417740500","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T10:37:33Z","timestamp":1509705453000},"page":"614-617","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Extensive cerebrovascular disease and stroke with prolonged prodromal symptoms as first presentation of perinatally-acquired human immunodeficiency virus infection in a young adult"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-894X","authenticated-orcid":false,"given":"TG","family":"Chigonda","sequence":"first","affiliation":[{"name":"Parirenyatwa Hospital, Harare, Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GT","family":"Chatora","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Baines Avenue, Harare, Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GW","family":"Ngwende","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RF","family":"Miller","sequence":"additional","affiliation":[{"name":"Research Department of Infection and Population Health, Institute for Global Health, University College London, London, UK"},{"name":"Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RA","family":"Ferrand","sequence":"additional","affiliation":[{"name":"Research Department of Infection and Population Health, Institute for Global Health, University College London, London, UK"},{"name":"Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK"},{"name":"Biomedical Research & Training Institute, Harare, Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"bibr1-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280302"},{"key":"bibr2-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550210078016"},{"key":"bibr3-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90379-3"},{"key":"bibr4-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002278"},{"key":"bibr5-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis271"},{"key":"bibr6-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis118"},{"key":"bibr7-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70205-3"},{"key":"bibr8-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1089\/108729101460065"},{"key":"bibr9-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200107010-00001"},{"key":"bibr10-0956462417740500","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2766"},{"key":"bibr11-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.643387"},{"key":"bibr12-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1159\/000157632"},{"key":"bibr13-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.12.022"},{"key":"bibr14-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.583856"},{"key":"bibr15-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.10.012"},{"key":"bibr16-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-012-0123-y"},{"key":"bibr17-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200109280-00029"},{"key":"bibr18-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1177\/1941874415583847"},{"key":"bibr19-0956462417740500","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833016ce"}],"container-title":["International Journal of STD &amp; 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