{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:09:10Z","timestamp":1787018950723,"version":"build-2736575974"},"reference-count":39,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["85810"],"award-info":[{"award-number":["85810"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>The development of lipodystrophy is associated with the long-term use of antiretroviral therapy (ART). We assessed agreement between patient-reported lipodystrophy and body composition measures using dual-energy X-ray absorptiometry (DXA) and developed objective measures to define lipoatrophy and lipohypertrophy in black South Africans. One hundred and eighty-seven ART-na\u00efve HIV-infected adults were enrolled in a 24-month longitudinal study. Self-reported information on regional fat loss and fat gain, anthropometry, and DXA measures were collected at baseline, three, six, 12, 18, and 24 months after starting ART. Receiver operating characteristic curves were used to describe the performance of anthropometric variables using change in limb and trunk fat measured by DXA, as the reference standard. The proportion of men and women who developed lipoatrophy and lipohypertrophy increased over the 24-month period, with lipoatrophy occurring more frequently in men (21% versus 10%). In women, lipoatrophy was best determined by thigh skinfold thickness (80.3% correctly classified) and mid-arm circumference (77.6% correctly classified). None of the anthropometric measures performed well for defining lipoatrophy in men. Anthropometric measures performed well for defining lipoatrophy in women, but not lipohypertrophy.<\/jats:p>","DOI":"10.1177\/0956462418778649","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:57:59Z","timestamp":1530061079000},"page":"1194-1203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Anthropometric definitions for antiretroviral-associated lipodystrophy derived from a longitudinal South African cohort with serial dual-energy X-ray absorptiometry measurements"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-6009","authenticated-orcid":false,"given":"Zulfa","family":"Abrahams","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Diabetic Medicine and Endocrinology, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Maartens","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetic Medicine and Endocrinology, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetic Medicine and Endocrinology, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"bibr1-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041811"},{"key":"bibr2-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-246"},{"key":"bibr3-0956462418778649","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1491"},{"key":"bibr4-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2010.543885"},{"key":"bibr5-0956462418778649","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.18.1.19033"},{"key":"bibr6-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12656-6"},{"key":"bibr7-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2013.793275"},{"key":"bibr8-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1086\/339866"},{"key":"bibr9-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir324"},{"key":"bibr10-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000229996.75116.da"},{"key":"bibr11-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:8:3:293"},{"key":"bibr12-0956462418778649","first-page":"839","volume":"66","author":"Abrahams Z","year":"2014","journal-title":"AIDS Res Ther"},{"key":"bibr13-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-8-210"},{"key":"bibr14-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-3-17"},{"key":"bibr15-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2007.0173"},{"key":"bibr16-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200301010-00015"},{"key":"bibr17-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31819c16f4"},{"key":"bibr18-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1310\/hct1005-314"},{"key":"bibr19-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.73"},{"key":"bibr20-0956462418778649","unstructured":"Department of Health. South African antiretroviral treatment guidelines, http:\/\/www.sahivsoc.org\/upload\/documents\/2013%20ART%20Guidelines-Short%20Combined%20FINAL%20draft%20guidelines%2014%20March%202013.pdf (accessed 18 October 2013)."},{"key":"bibr21-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200107270-00008"},{"key":"bibr22-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832b4377"},{"key":"bibr23-0956462418778649","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000183629.20041.bb"},{"key":"bibr24-0956462418778649","doi-asserted-by":"publisher","DOI":"10.2174\/157016211794582687"},{"key":"bibr25-0956462418778649","unstructured":"Valantin MA, Flandre P, Kolta S, et\u00a0al.  Fat tissue distribution changes in HIV-infected patients with viral suppression treated with darunavir\/ritonavir (DRV\/r) monotherapy versus 2 NRTIs DRV\/r in the MONOI-ANRS 136 randomized trial: results at 48 weeks. 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