{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:04:28Z","timestamp":1781615068934,"version":"3.54.5"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"UCLA Center for World Health"},{"DOI":"10.13039\/100018192","name":"UCLA Center for HIV Identification, Prevention and Treatment Services","doi-asserted-by":"crossref","award":["P30MH058107"],"award-info":[{"award-number":["P30MH058107"]}],"id":[{"id":"10.13039\/100018192","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017823","name":"UCLA Center for AIDS Research","doi-asserted-by":"crossref","award":["AI028697"],"award-info":[{"award-number":["AI028697"]}],"id":[{"id":"10.13039\/100017823","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>The SD BIOLINE HIV\/Syphilis Duo (SD BIOLINE DUO) rapid test is a dual rapid lateral flow immunoassay that detects antibodies to both human immunodeficiency virus (HIV) and Treponema pallidum (TP) \u2018syphilis\u2019 via fingerprick whole blood. We evaluated the field performance of the SD BIOLINE HIV\/Syphilis Duo test among two populations in Hanoi, Vietnam \u2013 men who have sex with men (MSM) and pregnant women. We also surveyed factors that influence participants\u2019 willingness to test for HIV and syphilis. This test has the potential to increase HIV and syphilis screening in low-resource settings. Patients who received healthcare services at a sexual health clinic for MSM and a district antenatal care center in Hanoi, Vietnam were recruited for the study. Participants with HIV and syphilis were intentionally recruited for adequate test performance evaluation via convenience sampling. At each facility, venipuncture blood specimens were obtained for reference testing for HIV and TP using SD BIOLINE HIV 1\/2 3.0 and TP particle agglutination, respectively. SD BIOLINE DUO was compared to the standard reference tests and sensitivity and specificity were calculated. We calculated 95% confidence interval (CI) using the exact binomial method. We used conjoint analysis to identify test attributes that are associated with participant likelihood to seek HIV and syphilis testing. Of 280 participants, 100 (35.7%) were MSM and 180 (64.3%) were pregnant women. Of MSM, 17 (17.0%) were HIV positive and 49 (49.0%) were TP seropositive. All women were negative for both HIV and syphilis antibodies. For HIV antibody testing, sensitivity and specificity were 100.0% (95% CI: 80.5\u2013100.0%) and 100.0% (95% CI: 98.6\u2013100.0%), respectively. For the syphilis antibody testing, sensitivity and specificity were 83.1% (95% CI: 71.0\u201391.6%) and 100.0% (95% CI: 98.3\u2013100.0%), respectively. Potential for false positives, preference for one blood draw over two, and shorter wait time for testing results were the highest ranked attributes by participants according to their willingness to test. The SD BIOLINE HIV\/Syphilis Duo rapid test demonstrated very good performance in this field setting and participants preferred attributes that aligned well with this test.<\/jats:p>","DOI":"10.1177\/0956462418802685","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:29:15Z","timestamp":1540268955000},"page":"173-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["A field evaluation of a rapid dual immunoassay for human immunodeficiency virus and syphilis antibodies, Hanoi, Vietnam"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5457-4080","authenticated-orcid":false,"given":"Keenan","family":"Withers","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Bristow","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Research and Training of AIDS, Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1486-1130","authenticated-orcid":false,"given":"Chrysovalantis","family":"Stafylis","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le M","family":"Giang","sequence":"additional","affiliation":[{"name":"Center for Research and Training of AIDS, Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D","family":"Klausner","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"},{"name":"Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"bibr1-0956462418802685","unstructured":"UNAIDS. HIV AIDS and estimates, http:\/\/www.unaids.org\/en\/regionscountries\/countries\/vietnam (2016, accessed 13 October 2017)."},{"key":"bibr2-0956462418802685","unstructured":"Ministry of Health National Institute of Hygiene and Epidemiology. HIV\/STI Integrated Biological and Behavioral Surveillance (IBBS) in Vietnam, http:\/\/nihe.org.vn\/farm\/nihe\/2016\/07\/21\/a80ec0a3-41c9-4bd3-a82f-3c04633b8051.pdf (2014, accessed 17 September 2018)."},{"key":"bibr3-0956462418802685","unstructured":"World Health Organization. Global incidence and prevalence of selected curable sexually transmitted infection, http:\/\/apps.who.int\/iris\/bitstream\/10665\/75181\/1\/9789241503839_eng.pdf?ua.1 (2008, accessed 17 September 2018)."},{"key":"bibr4-0956462418802685","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20965"},{"key":"bibr5-0956462418802685","unstructured":"The Global Fund to Fight AIDS, Tuberculosis and Malaria. TB and HIV concept note, http:\/\/www.unaids.org\/sites\/default\/files\/country\/documents\/VNM_narrative_report_2015.pdf (2014, accessed 17 September 2018)."},{"key":"bibr6-0956462418802685","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001396"},{"key":"bibr7-0956462418802685","unstructured":"World Health Organization. Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV and syphilis, http:\/\/apps.who.int\/iris\/bitstream\/10665\/112858\/1\/9789241505888_eng.pdf?ua.1&ua.1 (2014, accessed 17 September 2018)."},{"key":"bibr8-0956462418802685","doi-asserted-by":"publisher","DOI":"10.1080\/09540120701687026"},{"key":"bibr9-0956462418802685","unstructured":"Nguyen VTT, Trang HQ, Anh NTL, et\u00a0al. An innovative approach to triple elimination of mother-to-child transmission of HIV, syphilis and hepatitis B in Viet Nam. In: Presented at AIDS, Vancouver, Canada, 20 July 2015. World Health Organization. Western Pacific Region. http:\/\/www.who.int\/hiv\/pub\/posters\/poster_09.pdf?ua.1 (Presented at AIDS 2015, Vancouver, Canada, accessed 17 September 2018)."},{"key":"bibr10-0956462418802685","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052326"},{"key":"bibr11-0956462418802685","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052474"},{"key":"bibr12-0956462418802685","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.04.004"},{"key":"bibr13-0956462418802685","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2014.10.007"},{"key":"bibr14-0956462418802685","doi-asserted-by":"crossref","unstructured":"Gliddon HD, Peeling RW, Kamb ML, et\u00a0al. A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis\n                      Sex Transm Infect\n                      . Epub ahead of print 26 July 2017. 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